Periodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago, Chile.
Oral Pathology Laboratory, Faculty of Dentistry, Universidad Andrés Bello, Santiago, Chile.
Mediators Inflamm. 2018 Apr 2;2018:7806912. doi: 10.1155/2018/7806912. eCollection 2018.
Periodontitis is a chronic immuno-inflammatory disease in which the disruption of the balance between host and microbiota interactions is key to the onset and progression of the disease. The immune homeostasis associated with periodontal health requires a regulated immuno-inflammatory response, during which the presence of regulatory T cells (Tregs) is essential to ensure a controlled response that minimizes collateral tissue damage. Since Tregs modulate both innate and adaptive immunity, pathological conditions that may resolve by the acquisition of immuno-tolerance, such as periodontitis, may benefit by the use of Treg immunotherapy. In recent years, many strategies have been proposed to take advantage of the immuno-suppressive capabilities of Tregs as immunotherapy, including the and manipulation of the Treg compartment. Ongoing research in both basic and translational studies let us gain a better understanding of the diversity of Treg subsets, their phenotypic plasticity, and suppressive functions, which can be used as a substrate for new immunotherapies. Certainly, as our knowledge of Treg biology increases, we will be capable to develop new therapies designed to enhance the stability and function of Tregs during periodontitis.
牙周炎是一种慢性免疫炎症性疾病，其中宿主与微生物群相互作用的平衡破坏是疾病发生和进展的关键。与牙周健康相关的免疫稳态需要调节免疫炎症反应，在此期间，调节性 T 细胞 (Treg) 的存在对于确保控制反应从而最小化附带的组织损伤至关重要。由于 Treg 调节先天和适应性免疫，因此可以通过获得免疫耐受来解决的病理状况，例如牙周炎，可能会受益于 Treg 免疫疗法。近年来，已经提出了许多策略来利用 Treg 的免疫抑制能力作为免疫疗法，包括 Treg 群体的 和 操纵。基础和转化研究的持续研究使我们更好地了解 Treg 亚群的多样性、其表型可塑性和抑制功能，这些可以作为新免疫疗法的基础。当然，随着我们对 Treg 生物学的了解不断增加，我们将能够开发旨在增强 Treg 在牙周炎期间的稳定性和功能的新疗法。
