Zhang Chaoqi, Li Lifeng, Feng Kexin, Fan Daoyang, Xue Wenhua, Lu Jingli
Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Cell Physiol Biochem. 2017;43(6):2155-2169. doi: 10.1159/000484295. Epub 2017 Oct 25.
Studies in mice and humans have elucidated an important role for Tregs in promoting tissue repair and restoring tissue integrity. Emerging evidence has revealed that Tregs promoted wound healing and repair processes at multiple tissue sites, such as the heart, liver, kidney, muscle, lung, bone and central nervous system. The localization of repair Tregs in the lung, muscle and liver exhibited unique phenotypes and functions. Epidermal growth factor receptor, amphiregulin, CD73/CD39 and keratinocyte growth factor are important repair factors that are produced or expressed by repair Tregs; these factors coordinate with parenchymal cells to limit injury and promote repair. In addition, repair Tregs can be modulated by IL-33/ST2, TCR signals and other cytokines in the context of injured microenvironment cues. In this review, we provide an overview of the emerging knowledge about Treg-mediated repair in damaged tissues and organs.
对小鼠和人类的研究已阐明调节性T细胞（Tregs）在促进组织修复和恢复组织完整性方面的重要作用。新出现的证据表明，Tregs在多个组织部位促进伤口愈合和修复过程，如心脏、肝脏、肾脏、肌肉、肺、骨骼和中枢神经系统。修复性Tregs在肺、肌肉和肝脏中的定位表现出独特的表型和功能。表皮生长因子受体、双调蛋白、CD73/CD39和角质形成细胞生长因子是由修复性Tregs产生或表达的重要修复因子；这些因子与实质细胞协同作用以限制损伤并促进修复。此外，在受损微环境信号的背景下，修复性Tregs可被白细胞介素-33/ST2、TCR信号和其他细胞因子调节。在本综述中，我们概述了有关Tregs介导的受损组织和器官修复的新认识。
