and mutations in oral mucosal melanoma and a systematic review of the literature.

Oral mucosal melanoma (OMM) is an aggressive malignant tumor derived from melanocytes in the oral cavity. The genetic etiology of OMM has not been extensively investigated to date. In the present study, the aim was to detect novel gene mutations in patients with OMM. Mutation analysis of and was conducted by polymerase chain reaction. In addition, the relevant literature was searched using the PubMed database, and previous findings were compared with the results of the present study. Among the 9 patients with OMM examined, and mutations were detected, and these mutations were all observed at a frequency of 11.1% (1/9 patients). Notably, a novel mutation in 2 patients with OMM was identified by exome sequencing. In conclusion, the current study observed and mutations in patients with OMM, which may be of benefit for elucidating the underlying mechanism of OMM pathogenesis.