Mochtar Moerbono, Murasmita Alamanda, Irawanto M Eko, Julianto Indah, Kariosentono Harijono, Waskito Fajar
Dermatovenerology Department, Sebelas Maret University, Dr. Moewardi General Hospital, Surakarta, Indonesia.
Dermatovenerology Department, Gadjah Mada University, Dr. Sardjito' General Hospital, Yogyakarta, Indonesia.
Int J Inflam. 2018 Apr 1;2018:4141579. doi: 10.1155/2018/4141579. eCollection 2018.
Acne vulgaris is a multifactorial disease. Recent study showed that inflammation does have a central role in the formation of both inflammatory and noninflammatory lesions in acne vulgaris. There are various findings of proinflammatory cytokines related to acne vulgaris, but no previous study correlate interleukin- (IL-) 19 to acne vulgaris. This pilot study aims to look at difference in IL-19 serum concentration on degrees of severity of acne vulgaris.
This is an analytical observational cross-sectional study. Sample subjects were patients with acne vulgaris who met the inclusion criteria. Enzyme-linked immunosorbent assay (ELISA) study was applied to measure IL-19 serum.
Analysis test found statistically significant difference between IL-19 serum concentration of group of patients with mild acne vulgaris and that of group of patients with severe acne vulgaris. Moreover, analysis revealed significant difference between IL-19 serum concentration of group of patients with moderate acne vulgaris and that of group of patients with severe acne vulgaris.
There are differences in serum levels of IL-19 on the severity of acne vulgaris. The significant difference might show that inflammation has a core role in severity of acne vulgaris, and IL-19 might potentially be related to acne vulgaris.
寻常痤疮是一种多因素疾病。最近的研究表明，炎症在寻常痤疮的炎性和非炎性皮损形成中确实起着核心作用。关于寻常痤疮有多种促炎细胞因子的研究发现，但此前尚无研究将白细胞介素-（IL-）19与寻常痤疮相关联。这项初步研究旨在观察寻常痤疮严重程度不同时IL-19血清浓度的差异。
这是一项分析性观察性横断面研究。样本对象为符合纳入标准的寻常痤疮患者。采用酶联免疫吸附测定（ELISA）法检测血清IL-19。
分析测试发现，轻度寻常痤疮患者组与重度寻常痤疮患者组的IL-19血清浓度存在统计学显著差异。此外，分析还显示，中度寻常痤疮患者组与重度寻常痤疮患者组的IL-19血清浓度存在显著差异。
寻常痤疮严重程度不同时，IL-19血清水平存在差异。这一显著差异可能表明炎症在寻常痤疮严重程度中起核心作用，且IL-19可能与寻常痤疮相关。
