Department of Dermatology, Venereology and Andrology, Ain Shams University, Cairo, Egypt.
J Cosmet Dermatol. 2021 Sep;20(9):3034-3040. doi: 10.1111/jocd.13977. Epub 2021 Feb 13.
Acne vulgaris (AV) is a common chronic inflammatory disorder of the pilosebaceous unit among adolescents and young adults. Inflammation does have a central role in formation of both inflammatory and noninflammatory acne lesions with production of proinflammatory cytokines.
To measure serum levels of interleukin 19 (IL-19) in acne vulgaris patients with different severities, and compare it with healthy controls, to evaluate its role in pathogenesis of acne vulgaris and correlate it with acne severity.
This study included 120 subjects, aged 18-30 years, divided into four groups, 30 in each; mild, moderate, and severe AV patients groups according to acne severity as well as apparently healthy controls group of matched age and sex with no previous history of acne or active acne. Each patient was subjected to history taking, general and dermatological examination with assessment of acne severity. Serum IL-19 levels of both patients and controls were also measured using quantitative enzyme-linked immunosorbent assay (ELISA).
Results revealed significant difference in serum IL-19 levels between acne patients and controls, being higher in the former group (P value is < 0.001). Moreover, the rise in serum IL-19 levels was significantly proportional to the increased acne severity (P value < 0.001).
IL-19 is related to the etiopathological inflammatory process of acne vulgaris and correlates with acne severity. It could be proposed as a prognostic inflammatory marker for acne vulgaris.
寻常痤疮（AV）是青少年和年轻人中一种常见的毛囊皮脂腺单位的慢性炎症性疾病。炎症确实在炎症性和非炎症性痤疮病变的形成中起着核心作用，产生促炎细胞因子。
测量不同严重程度寻常痤疮患者的血清白细胞介素 19（IL-19）水平，并将其与健康对照组进行比较，评估其在寻常痤疮发病机制中的作用，并与痤疮严重程度相关。
本研究纳入了 120 名年龄在 18-30 岁之间的受试者，分为 4 组，每组 30 名；根据痤疮严重程度分为轻度、中度和重度 AV 患者组，以及年龄和性别匹配的无既往痤疮或活动性痤疮史的健康对照组。对每位患者进行病史采集、全身和皮肤科检查，并评估痤疮严重程度。还使用定量酶联免疫吸附试验（ELISA）测量患者和对照组的血清 IL-19 水平。
结果显示，痤疮患者和对照组的血清 IL-19 水平存在显著差异，前者组更高（P 值<0.001）。此外，血清 IL-19 水平的升高与痤疮严重程度的增加呈显著比例关系（P 值<0.001）。
IL-19 与寻常痤疮的病因发病炎症过程有关，并与痤疮严重程度相关。它可以被提出作为寻常痤疮的预后炎症标志物。
