Szigeti Balázs, Roth Yosef D, Sekar John A P, Goldberg Arthur P, Pochiraju Saahith C, Karr Jonathan R
Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, 10029, USA.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, 10029, USA.
Curr Opin Syst Biol. 2018 Feb;7:8-15. doi: 10.1016/j.coisb.2017.10.005. Epub 2017 Nov 9.
Whole-cell dynamical models of human cells are a central goal of systems biology. Such models could help researchers understand cell biology and help physicians treat disease. Despite significant challenges, we believe that human whole-cell models are rapidly becoming feasible. To develop a plan for achieving human whole-cell models, we analyzed the existing models of individual cellular pathways, surveyed the biomodeling community, and reflected on our experience developing whole-cell models of bacteria. Based on these analyses, we propose a plan for a project, termed the , to achieve human whole-cell models. The foundations of the plan include technology development, standards development, and interdisciplinary collaboration.
人类细胞的全细胞动力学模型是系统生物学的核心目标。这样的模型有助于研究人员理解细胞生物学，并帮助医生治疗疾病。尽管存在重大挑战，但我们相信人类全细胞模型正迅速变得可行。为了制定实现人类全细胞模型的计划，我们分析了现有的单个细胞通路模型，调查了生物建模界，并反思了我们构建细菌全细胞模型的经验。基于这些分析，我们提出了一个名为“ ”的项目计划，以实现人类全细胞模型。该计划的基础包括技术开发、标准制定和跨学科合作。
