Zhou Lanting, Feng Yanting, Dai Jingxing, Ouyang Jun
Medical College, Hubei University of Arts and Science, Xiangyang Hubei, 441053, P.R.China;Department of Anatomy, Southern Medical University, Guangzhou Guangdong, 510515, P.R.China.
Department of Anatomy, Southern Medical University, Guangzhou Guangdong, 510515, P.R.China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2017 Dec 15;31(12):1506-1511. doi: 10.7507/1002-1892.201706076.
To review the research progress of miRNA regulation in the differentiation of adipose-derived stem cells (ADSCs).
The recent literature associated with miRNAs and differentiation of ADSCs was reviewed. The regulatory mechanism was analyzed in detail and summarized.
The results indicate that the expression of miRNAs changes during differentiation of ADSCs. In addition, miRNAs regulate the differentiation of ADSCs into adipocytes, osteoblasts, chondrocytes, neurons, and hepatocytes by regulating the signaling pathways involved in cell differentiation.
Through controlling the differentiation of ADSCs by miRNAs, the suitable seed cell for tissue engineering can be established. The review will provide a theoretical basis for molecular targeted therapy and stem cell therapy in clinic.
综述微小RNA（miRNA）调控脂肪来源干细胞（ADSCs）分化的研究进展。
回顾近期与miRNA和ADSCs分化相关的文献。详细分析并总结其调控机制。
结果表明，在ADSCs分化过程中miRNA的表达发生变化。此外，miRNA通过调控参与细胞分化的信号通路来调节ADSCs向脂肪细胞、成骨细胞、软骨细胞、神经元和肝细胞的分化。
通过miRNA控制ADSCs的分化，可为组织工程建立合适的种子细胞。本综述将为临床分子靶向治疗和干细胞治疗提供理论依据。
