一种从楝科植物印楝（Azadirachta Juss.）叶子中提取的新型内酰胺28-降柠檬苦素。

A new lactam 28-norlimonoid from the leaves of A. Juss. (Meliaceae).

作者信息

Nguyen Nhi Y T, Dang Phu H, Nguyen Van T T, Dang Phuc H, Tran Quan L

机构信息

a Faculty of Chemistry , VNUHCM-University of Science , Ho Chi Minh City , Vietnam.

b Theoretical Physics Research Group , Advanced Institute of Materials Science, Ton Duc Thang University , Ho Chi Minh City , Vietnam.

出版信息

Nat Prod Res. 2019 Jul;33(13):1903-1908. doi: 10.1080/14786419.2018.1479700. Epub 2018 May 28.

DOI:10.1080/14786419.2018.1479700

PMID:29806497

Abstract

From an EtOAc-soluble fraction of the leaves of , one new lactam 28-norlimonoid named nimbandiolactam-21 (), together with 2 known limonoids ( and ) were isolated. Their relative structures were elucidated based on NMR spectroscopic analysis. Nimbandiolactone-23 () showed the most potent -glucosidase inhibitory activity, with an IC value of 38.7 μM. Compound represents the first naturally occurring example of a 28-norlimonoid having the lactam moiety. The plausible biosynthetic pathway for the formation of lactam moiety in was proposed.

摘要

从[植物名称]叶片的乙酸乙酯可溶部分中，分离出一种名为nimbandiolactam - 21的新型内酰胺28 - 降柠檬苦素，以及2种已知的柠檬苦素（[柠檬苦素1名称]和[柠檬苦素2名称]）。基于核磁共振光谱分析阐明了它们的相对结构。Nimbandiolactone - 23显示出最强的α - 葡萄糖苷酶抑制活性，IC值为38.7 μM。化合物[具体化合物编号]代表了首个具有内酰胺部分的天然存在的28 - 降柠檬苦素实例。提出了在[化合物名称]中形成内酰胺部分的可能生物合成途径。