从印楝（Neem）叶中提取的生物活性柠檬苦素。

Bioactive limonoids from the leaves of Azaridachta indica (Neem).

机构信息

Laboratorio de Medicamentos Organicos Sector Campo de Oro, Departamento de Farmacognosia y Medicamentos Organicos, Universidad de Los Andes , detras del HULA, Mérida, 5101, Venezuela.

出版信息

J Nat Prod. 2014 Mar 28;77(3):596-602. doi: 10.1021/np400863d. Epub 2014 Feb 5.

DOI:10.1021/np400863d

PMID:24499352

Abstract

Eight new limonoids (1-8) and one new phenol glycoside (9), along with six known compounds, were isolated from the leaves of Azaridachta indica. The structures of 1-9 were elucidated on the basis of spectroscopic data analysis. Compounds isolated were assayed for their cytotoxicity against different cancer cell lines. Moreover, their ability to interact with the molecular chaperone Hsp90, affecting its biological activity, was tested.

摘要

从印度黄檀的叶子中分离得到了 8 个新的柠檬苦素（1-8）和 1 个新的酚糖苷（9），以及 6 个已知化合物。基于光谱数据分析，确定了 1-9 的结构。对分离得到的化合物进行了细胞毒性测试，以评估其对不同癌细胞系的抑制活性。此外，还测试了它们与分子伴侣 Hsp90 相互作用的能力，以及对其生物活性的影响。