Portaro Simona, Brizzi Teresa, Naro Antonino, Conti Nibali Valeria, Morabito Rosa, Bramanti Alessia, Calabrò Rocco Salvatore
1 Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Centro Neurolesi Bonino-Pulejo, Messina, Italy.
2 Dipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), University of Palermo, Palermo, Italy.
J Int Med Res. 2018 Jul;46(7):2933-2937. doi: 10.1177/0300060517735936. Epub 2018 May 28.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting upper and lower motor neurones. It can be either familial (fALS) or sporadic (sALS). ALS is characterized by muscle weakness and atrophy that can involve the limbs and trunk (i.e. the spinal form of the disease) or speech and swallowing (i.e. the bulbar form). The aetiology of sALS remains unclear although a gene-environment interaction has been proposed as a concomitant trigger for the neurodegenerative process together with viral infections, smoking, heavy metals and pesticide exposure. Herein, we report the case of a 67-year-old woman who experienced an acute onset of bulbar ALS with an atypical clinical course that was probably triggered by a bout of influenza.
肌萎缩侧索硬化症（ALS）是一种影响上下运动神经元的神经退行性疾病。它可以是家族性的（fALS）或散发性的（sALS）。ALS的特征是肌肉无力和萎缩，可累及四肢和躯干（即疾病的脊髓型）或言语和吞咽（即延髓型）。尽管有人提出基因-环境相互作用与病毒感染、吸烟、重金属和接触农药一起是神经退行性过程的伴随触发因素，但sALS的病因仍不清楚。在此，我们报告一例67岁女性病例，该患者急性起病，患有延髓型ALS，临床病程不典型，可能由一次流感发作引发。
