Auguste Bourne L, Bargman Joanne M
Division of Nephrology, University Health Network, Toronto, ON, Canada.
Semin Dial. 2018 Sep;31(5):445-448. doi: 10.1111/sdi.12712. Epub 2018 May 28.
Coping with the transition from end-stage kidney disease to dialysis can be challenging for patients and their care partners. Introducing incident dialysis patients to incremental forms of dialysis is associated with better quality of life and reduced cost. Incremental hemodialysis (HD) has generated significant interest over the last decade with treatments that focus on clinical criteria rather than prespecified Kt/V targets. Incremental peritoneal dialysis (PD) has traditionally focused on the sum of residual renal and peritoneal clearances to achieve a specific Kt/V value. Gradual increases in the PD dose were prescribed as the residual kidney function declined. Adopting a new approach to incremental PD similar to what has been done for incremental HD would obviate the need for Kt/V and focus exclusively on clinical criteria. New incremental PD may be considered less disruptive to incident dialysis patients, and may be more likely to be accepted as treatment. It will also reduce our obsession with small solute kinetics and enhance encounters with patients by focusing instead on the holisitc clinical assessment.
对于患者及其护理伙伴而言,应对从终末期肾病过渡到透析的过程可能具有挑战性。让初治透析患者采用渐进式透析形式与更好的生活质量和更低的成本相关。在过去十年中,渐进性血液透析(HD)通过专注于临床标准而非预先设定的Kt/V目标的治疗方法引起了广泛关注。传统上,渐进性腹膜透析(PD)侧重于残余肾和腹膜清除率的总和,以达到特定的Kt/V值。随着残余肾功能下降,逐步增加PD剂量。采用一种类似于渐进性HD的渐进性PD新方法将无需Kt/V,而仅专注于临床标准。新的渐进性PD可能被认为对初治透析患者的干扰较小,并且更有可能被接受为治疗方法。它还将减少我们对小分子溶质动力学的痴迷,并通过专注于整体临床评估来增加与患者的接触。