癌症代谢中的线粒体：时机已到的细胞器？
Mitochondria in cancer metabolism, an organelle whose time has come?
机构信息
Department of Cancer Biology, Comprehensive Cancer Center of Wake Forest University, United States.
Department of Cancer Biology, Comprehensive Cancer Center of Wake Forest University, United States; Section on Hematology and Oncology, Comprehensive Cancer Center of Wake Forest University, United States; Rafael Pharmaceuticals, Newark, NJ, United States.
出版信息
Biochim Biophys Acta Rev Cancer. 2018 Aug;1870(1):96-102. doi: 10.1016/j.bbcan.2018.05.005. Epub 2018 May 26.
Abstract
Mitochondria have long been controversial organelles in cancer. Early discoveries in cancer metabolism placed much emphasis on cytosolic contributions. Initial debate focused on if mitochondria had a role in cancer formation and progression at all. More recently the contributions of mitochondria to cancer development and progression have become firmly established. This has led to the identification of novel targets and inhibitors being studied as new therapeutic approaches. This review will summarize the role of mitochondria in cancer and highlight several agents under development.
摘要
线粒体在癌症中一直是一个有争议的细胞器。癌症代谢的早期发现非常强调细胞质的贡献。最初的争论集中在线粒体是否在癌症的形成和进展中起作用。最近，线粒体对癌症发展和进展的贡献已经得到了确立。这导致了新的治疗方法的研究，确定了新的靶标和抑制剂。本文综述了线粒体在癌症中的作用，并强调了几种正在开发的药物。
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