Department of Internal Diseases, Angiology and Physical Medicine, Center for Laser Diagnostics and Therapy, Specialist Hospital N(o)2, Batorego Street 15, 41-902 Bytom, Poland(1); School of Medicine with the Division of Dentistry in Zabrze, Center for Laser Diagnostics and Therapy, Department of Internal Diseases, Angiology and Physical Medicine, Medical University of Silesia, Batorego Street 15, 41-902 Bytom, Poland(2).
School of Medicine with the Division of Dentistry in Zabrze, Center for Laser Diagnostics and Therapy, Department of Internal Diseases, Angiology and Physical Medicine, Medical University of Silesia, Batorego Street 15, 41-902 Bytom, Poland(2).
Photodiagnosis Photodyn Ther. 2018 Sep;23:63-67. doi: 10.1016/j.pdpdt.2018.05.015. Epub 2018 May 26.
The search for new diagnostic and therapeutic procedures is an essential task in contemporary oncology. The purpose of our study was the evaluation of the practical usefulness of autofluorescence endoscopy (AFE) using the Onco-LIFE system, compared with the use of white light endoscopy (WLE), and the estimation of the correlation between the histopathological evaluation with the degree of lesions' Numerical Color Value (NCV index) and the method's sensitivity and specificity valuation.
67 patients were analyzed at the Center for Laser Diagnostics and Therapy. All patients previously had a gastrointestinal tract tumor, which appeared malignant, but without histopathological confirmation. We measured NCV, estimated the correlation of the clinical diagnosis based on histopathological evaluation with the degree of NCV index from gastrointestinal lesions, and calculated the sensitivity and specificity of this method.
In the group of 67 patients, we found 44 cases of primary or secondary cancers and 7 cases of non-epithelial malignancies. In this group (51 patients) we identified 13 colorectal cancers and 38 upper gastrointestinal cancers. Based on the NCV index at NCV > 1.0, we revealed, that the sensitivity for malignant neoplastic lesions was 100% and the specificity was 73%, while for NCV > 1.5, the sensitivity for malignant neoplastic lesions was 86% and the specificity 100%.
AFE using the Onco-LIFE system is a helpful tool to perform targeted biopsies at the outset. A significant correlation was found between lesions' NCV index and the grade of dysplasia or tumor malignancy. AFE sensitivity and specificity is higher than WLE. Further studies are needed, especially performed by expert endoscopists.
在当代肿瘤学中，寻找新的诊断和治疗方法是一项至关重要的任务。我们的研究目的是评估使用 Onco-LIFE 系统的自发荧光内镜（AFE）的实际用途，与使用白光内镜（WLE）相比，并评估组织病理学评估与病变数值颜色值（NCV 指数）之间的相关性，以及该方法的敏感性和特异性估值。
在激光诊断与治疗中心分析了 67 名患者。所有患者之前都有胃肠道肿瘤，表现为恶性，但没有组织病理学证实。我们测量了 NCV，根据组织病理学评估估计了基于临床诊断与胃肠道病变 NCV 指数之间的相关性，并计算了该方法的敏感性和特异性。
在 67 名患者中，我们发现 44 例原发性或继发性癌症和 7 例非上皮性恶性肿瘤。在这组（51 名患者）中，我们发现 13 例结直肠癌和 38 例上胃肠道癌。基于 NCV > 1.0 的 NCV 指数，我们发现恶性肿瘤病变的敏感性为 100%，特异性为 73%，而 NCV > 1.5 时，恶性肿瘤病变的敏感性为 86%，特异性为 100%。
使用 Onco-LIFE 系统的 AFE 是一种有用的工具，可以在一开始就进行靶向活检。病变的 NCV 指数与异型增生或肿瘤恶性程度之间存在显著相关性。AFE 的敏感性和特异性高于 WLE。需要进一步研究，特别是由专家内镜医生进行的研究。
