Lehtonen Šárka, Höytyläinen Ida, Voutilainen Jenni, Sonninen Tuuli-Maria, Kuusisto Johanna, Laakso Markku, Hämäläinen Riikka H, Oksanen Minna, Koistinaho Jari
A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland; Neuroscience Center, University of Helsinki, Finland.
A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Stem Cell Res. 2018 Jul;30:96-99. doi: 10.1016/j.scr.2018.05.014. Epub 2018 May 19.
An amyloid precursor protein (APP) A673T mutation was found to be protective against Alzheimer's disease (AD) and cognitive decline in the Icelandic population and to associate with decreased levels of plasma β-amyloid in a Finnish population-based cohort. Human fibroblasts from a Finnish male individual carrying the protective mutation were used to generate integration-free induced pluripotent stem cell (iPSCs) line by Sendai virus technology. The iPSC line retained the mutation and expressed pluripotency markers, had a normal karyotype and differentiated into all three germ layers.
在冰岛人群中发现淀粉样前体蛋白（APP）A673T突变对阿尔茨海默病（AD）和认知衰退具有保护作用，并且在一个基于芬兰人群的队列中该突变与血浆β-淀粉样蛋白水平降低相关。利用仙台病毒技术，从一名携带该保护性突变的芬兰男性个体的人成纤维细胞中生成了无整合诱导多能干细胞（iPSC）系。该iPSC系保留了该突变并表达多能性标志物，具有正常的核型，且能分化为所有三个胚层。
