Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California.
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California.
Fertil Steril. 2018 Jun;109(6):1097-1104.e1. doi: 10.1016/j.fertnstert.2018.02.127. Epub 2018 May 25.
To characterize the degree of decision regret following elective oocyte cryopreservation (EOC) for social indications, and identify factors associated with regret.
Retrospective cohort survey study.
Academic center.
Two hundred one women who underwent EOC for fertility preservation between 2012 and 2016.
None.
Decision Regret Scale (DRS) score, from 0-100, with a cut-off >25 indicative of moderate to severe regret; and attitudes regarding decision satisfaction.
Median DRS score was 0 (interquartile range 0-15) and the mean was 10 (range 0-90). Thirty-three women (16%) experienced moderate to severe decision regret. Factors associated with decision regret included: number of eggs frozen, perceived adequacy of information prior to EOC, adequacy of emotional support during EOC, and patient-estimated probability of achieving a live birth using their banked eggs. In a multivariate logistic model, increased perceived adequacy of information (adjusted odds ratio 0.63, 95% confidence interval 0.42-0.97) and patient-estimated probability of achieving a live birth (adjusted odds ratio 0.80, 95% confidence interval 0.67-0.96) were associated with reduced odds of regret. One hundred sixty-seven women (88%) reported increased control over reproductive planning following EOC. One hundred eighty-three (89%) affirmed they will be happy they froze eggs, even if they never use them.
The risk of decision regret following EOC is non-negligible. Low number of mature oocytes cryopreserved is a risk factor for increased regret, while perceptions of adequate information and emotional support, and increased patient-estimates of achieving a live birth using banked eggs are associated with reduced risk of regret.
描述因社会因素选择进行卵子冷冻保存（EOC）后的决策后悔程度，并确定与后悔相关的因素。
回顾性队列调查研究。
学术中心。
2012 年至 2016 年间进行生育力保存而接受 EOC 的 201 名女性。
无。
决策后悔量表（DRS）评分，0-100 分，>25 分表示中度至重度后悔；以及对决策满意度的态度。
中位数 DRS 评分为 0（四分位距 0-15），平均值为 10（范围 0-90）。33 名女性（16%）经历了中度至重度决策后悔。与决策后悔相关的因素包括：冷冻卵子的数量、EOC 前对信息的感知充足度、EOC 期间情绪支持的充足度，以及患者对使用其冻存卵子实现活产的预估概率。在多变量逻辑模型中，增加感知到的信息充足度（调整后的优势比 0.63，95%置信区间 0.42-0.97）和患者对实现活产的预估概率（调整后的优势比 0.80，95%置信区间 0.67-0.96）与降低后悔的可能性相关。167 名女性（88%）报告说，EOC 后对生殖计划的控制有所增强。183 名女性（89%）表示，即使他们从未使用过冻存的卵子，他们也会为自己冷冻卵子而感到高兴。
EOC 后决策后悔的风险不容忽视。冷冻的成熟卵子数量少是后悔增加的危险因素，而对信息和情绪支持的感知充足度增加，以及对使用冻存卵子实现活产的预估概率增加，与降低后悔的风险相关。
