胃泌素释放肽在体外是小细胞肺癌的一种选择性促分裂原。
Gastrin releasing peptide is a selective mitogen for small cell lung carcinoma in vitro.
作者信息
Weber S, Zuckerman J E, Bostwick D G, Bensch K G, Sikic B I, Raffin T A
出版信息
J Clin Invest. 1985 Jan;75(1):306-9. doi: 10.1172/JCI111690.
Abstract
Human small cell lung carcinoma (SCLC) cells have been shown to contain significant levels of a bombesin-immunoreactive peptide. The 27-amino acid peptide, gastrin releasing peptide (GRP), has recently been shown to be responsible for the bombesin-like immunoreactivity found in SCLC cells. Among four lung cancer cell lines examined in vitro, GRP exhibited mitogenic activity for two SCLC subtypes, but not for a squamous carcinoma or adenocarcinoma lung cell line. The mitogenicity of the GRP molecule has been isolated to the carboxyterminal fragment, designated GRP 14-27, which is in part homologous to bombesin. The aminoterminal fragment, GRP 1-16, is no homologous to bombesin and exhibits no mitogenic activity. Thus, GRP may be an important growth regulating or autocrine factor in human SCLC.
摘要
已证明人类小细胞肺癌（SCLC）细胞含有高水平的蛙皮素免疫反应性肽。最近发现，由27个氨基酸组成的胃泌素释放肽（GRP）是SCLC细胞中发现的类蛙皮素免疫反应性的原因。在体外检测的四种肺癌细胞系中，GRP对两种SCLC亚型具有促有丝分裂活性，但对鳞状细胞癌或腺癌肺癌细胞系则无此活性。GRP分子的促有丝分裂活性已定位到羧基末端片段，命名为GRP 14 - 27，它与蛙皮素部分同源。氨基末端片段GRP 1 - 16与蛙皮素不同源，且无促有丝分裂活性。因此，GRP可能是人类SCLC中一种重要的生长调节或自分泌因子。
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