Morimoto T, Tanaka T, Komaki K, Sasa M, Monden Y, Kumagai H, Otsuka H
School of Medical Sciences, University of Tokushima, Japan.
Surg Today. 1993;23(7):656-60. doi: 10.1007/BF00311918.
It is very unusual for a carcinoma of the breast to coexist with a phyllodes tumor, or for a carcinoma to arise within a fibroadenoma. We present herein an extremely rare case of lobular carcinoma in situ arising in a fibroadenoma, associated with a malignant phyllodes tumor in the opposite breast. A 49-year-old woman was admitted to our hospital with a large mass in the right breast and a small mass in the left breast. Microscopic examination of biopsy materials revealed a malignant phyllodes tumor in the right breast and a fibroadenoma in the left breast, for which a right standard radical mastectomy and left lumpectomy were performed. Microscopic findings of the material excised from the left breast showed the presence of multiple lobular carcinoma in situ within the tumor mass of the fibroadenoma. However, histological examination did not detect any metastasis to the bilateral axillary lymph nodes. To our knowledge this is the only such case ever to be reported in Japan.
乳腺癌与叶状肿瘤共存，或癌在纤维腺瘤内发生的情况非常罕见。我们在此报告一例极其罕见的病例，即原位小叶癌发生于纤维腺瘤内，并伴有对侧乳腺的恶性叶状肿瘤。一名49岁女性因右乳有一较大肿块和左乳有一较小肿块而入住我院。活检材料的显微镜检查显示右乳为恶性叶状肿瘤，左乳为纤维腺瘤，遂行右乳标准根治性乳房切除术和左乳肿块切除术。从左乳切除的材料的显微镜检查结果显示，在纤维腺瘤的肿瘤块内存在多个原位小叶癌。然而，组织学检查未发现双侧腋窝淋巴结有任何转移。据我们所知，这是日本报告的唯一此类病例。
