Zakusov V V, Ostrovskaya R U, Markovitch V V, Molodavkin G M, Bulayev V M
Arch Int Pharmacodyn Ther. 1975 Apr;214(2):188-205.
Diazepam was shown to increase postexcitatory inhibition within the brain cortex as revealed by its influence upon the recovery cycles both of intracortical and primary responses. The specific interrelationship between diazepam and some drugs affecting brain GABA level suggests the possibility of a GABA mediated mechanism in the diazepam effect. The sensitivity of the brain cortex to diazepam is not lower than that of the amygdala and significantly higher than that of the hippocampus.
地西泮可增强大脑皮质内的兴奋性后抑制，这一点可从其对皮质内反应和初级反应恢复周期的影响中看出。地西泮与一些影响脑γ-氨基丁酸（GABA）水平的药物之间的特定相互关系提示，在地西泮的作用中可能存在GABA介导的机制。大脑皮质对地西泮的敏感性不低于杏仁核，且显著高于海马体。
