Kramp P, Hemmingsen R, Rafaelsen O J
Psychiatry Res. 1979 Oct;1(2):161-71. doi: 10.1016/0165-1781(79)90057-x.
Magnesium in plasma, erythrocytes, and cerebrospinal fluid (CSF) was measured immediately after hospital admission in 9 patients with delirium tremens (DT) and 11 patients with impending DT. Blood samples were taken daily during the acute state; a second lumbar puncture was performed when the patient's condition had improved. Plasma magnesium was low in patients with DT during the first days of the acute state and then spontaneously normalized. Normal plasma magnesium was consistently seen among patients with impending DT. Magnesium in erythrocytes and CSF was normal in both diagnostic categories. Patients with a high blood-alcohol concentration (BAC) at admission had a decreasing plasma magnesium, patients with a low BAC had a moderately increasing plasma magnesium, and patients with a BAC at nil had a more marked increase in plasma toms or with their duration. This finding, combined with the normal CSF magnesium and the lack of correlation between plasma and CSF magnesium, indicates that disturbances in magnesium metabolism do not play a role in the etiology or pathogenesis of DT; but it may be that disturbances in magnesium metabolism contribute to the development of alcoholic encephalopathy.
对9例震颤谵妄（DT）患者和11例即将发生DT的患者在入院后立即测定其血浆、红细胞和脑脊液（CSF）中的镁含量。在急性期每天采集血样；当患者病情好转时进行第二次腰椎穿刺。急性状态的头几天，DT患者的血浆镁含量较低，随后自发恢复正常。即将发生DT的患者血浆镁含量一直正常。在这两种诊断类别中，红细胞和脑脊液中的镁含量均正常。入院时血酒精浓度（BAC）高的患者血浆镁含量下降，BAC低的患者血浆镁含量适度增加，BAC为零的患者血浆镁含量增加更为明显，与抽搐发作或其持续时间无关。这一发现，结合脑脊液镁含量正常以及血浆和脑脊液镁含量之间缺乏相关性，表明镁代谢紊乱在DT的病因或发病机制中不起作用；但可能是镁代谢紊乱促成了酒精性脑病的发展。
