Sullivan J L, Coffey C E, Basuk B, Cavenar J O, Maltbie A A, Zung W W
Biol Psychiatry. 1980 Feb;15(1):113-20.
Reduced platelet MAO activity has been previously reported as a biochemical marker for a subgroup of psychiatric patients, including some chronic schizophrenics. As tryptamine metabolism appears to be sensitive to alterations in MAO activity, urinary tryptamine excretion was measured in chronic schizophrenics with low platelet MAO activity, chronic schizophrenics with normal platelet MAO activity, and age-matched and sex-matched controls. The increased urinary tryptamine excretion observed in chronic schizophrenics with low platelet MAO activity may reflect a pathophysiologic mechanism associated with low MAO activity.
血小板单胺氧化酶（MAO）活性降低先前已被报道为包括一些慢性精神分裂症患者在内的一部分精神病患者的生化标志物。由于色胺代谢似乎对MAO活性的改变敏感，因此对血小板MAO活性低的慢性精神分裂症患者、血小板MAO活性正常的慢性精神分裂症患者以及年龄和性别匹配的对照组进行了尿色胺排泄量的测定。血小板MAO活性低的慢性精神分裂症患者中观察到的尿色胺排泄增加可能反映了与低MAO活性相关的病理生理机制。
