Baron M, Gruen R, Levitt M, Kane J
Psychiatry Res. 1984 Mar;11(3):205-9. doi: 10.1016/0165-1781(84)90069-6.
Platelet monoamine oxidase activity (MAO) was determined in 39 unmedicated chronic schizophrenic patients and 88 normal control subjects. Platelet MAO activity did not distinguish paranoid from nonparanoid patients or patients who met Taylor and Abrams criteria for narrowly defined schizophrenia from other schizophrenics. Enzyme activity was not related to either prognostic scores or age at onset of illness. MAO activity was decreased in patients compared to controls, and was lower in males than in females. Our findings indicate that clinical phenomenology, as defined in the present study, is of limited use in identifying biological subtypes of schizophrenia with deviant platelet MAO activity.
测定了39例未接受药物治疗的慢性精神分裂症患者和88例正常对照者的血小板单胺氧化酶活性（MAO）。血小板MAO活性无法区分偏执型与非偏执型患者，也无法区分符合泰勒和艾布拉姆斯狭义精神分裂症标准的患者与其他精神分裂症患者。酶活性与预后评分或发病年龄均无关。与对照组相比，患者的MAO活性降低，且男性低于女性。我们的研究结果表明，本研究中所定义的临床现象学，在识别血小板MAO活性异常的精神分裂症生物学亚型方面作用有限。
