Tereshchenko I P, Kashulina A P, Aleksandrova L M, Rudenko T S, Zhukova N I
Eksp Onkol. 1985;7(1):27-30.
Structural and functional state of erythrocyte surface membrane was studied in C3H and C57B1/6 mice as well as in Wistar rats after 20-methylcholanthrene administration. It is shown that mice genetically susceptible to tumor growth as compared with mice resistant to carcinogenesis are characterized by an increased level of spinous erythrocytes (echinocytosis), higher membrane microviscosity and a tendency to increase polarity of their membrane lipid bilayer in the region of hydrophobic spine sound localization. The growth of chemically induced sarcomas was also accompanied by echinocytosis but with opposite changes in microviscosity and polarity of the erythrocyte membrane lipid bilayer. It is supposed that spinous erythrocyte transformation induced by different causes is based on different physicochemical factors.
研究了给予20-甲基胆蒽后C3H和C57B1/6小鼠以及Wistar大鼠红细胞表面膜的结构和功能状态。结果表明，与对致癌作用有抗性的小鼠相比，对肿瘤生长具有遗传易感性的小鼠的特征在于棘状红细胞水平升高（棘形红细胞增多症）、膜微粘度更高，并且在疏水脊柱声定位区域其膜脂双层的极性有增加的趋势。化学诱导肉瘤的生长也伴有棘形红细胞增多症，但红细胞膜脂双层的微粘度和极性发生相反变化。据推测，由不同原因诱导的棘状红细胞转化基于不同的物理化学因素。
