Centro de Investigación y Desarrollo en Materiales Avanzados y Almacenamiento de Energía de Jujuy-CIDMEJu, Centro de Desarrollo Tecnológico General Manuel Savio, Palpalá, 4612, Jujuy, Argentina.
Grupo de Electroanalítica (GEANA), Departamento de Química, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Agencia Postal Nº 3, 5800, Río Cuarto, Córdoba, Argentina.
Food Chem Toxicol. 2018 Aug;118:460-470. doi: 10.1016/j.fct.2018.05.057. Epub 2018 May 26.
Sterigmatocystin is a carcinogenic compound that affects several species of crops and several species of experimental animals. The sterigmatocystin biosynthetic pathway is the best known and most studied. The International Agency for Research on Cancer classifies sterigmatocystin in the Group 2B. Three groups of analytical methods to determine sterigmatocystin in food can be found: chromatographic, ELISA immunoassays and chemical sensors. In addition, sterigmatocystin is a precursor of aflatoxin B in those cases where cereals and/or food are contaminated with fungi capable of producing aflatoxins. Chemical structures of sterigmatocystin and aflatoxin B are similar. These mycotoxins are pathogens of animals and cereals, producing a major economic impact on biotechnology and agricultural and food industries. This review summarizes different aspects related to sterigmatocystin such as its biosynthesis, toxicological studies and analytical methods for its determination.
赭曲霉素是一种致癌化合物，会影响几种作物和几种实验动物。赭曲霉素生物合成途径是最著名和研究最多的。国际癌症研究机构将赭曲霉素归类为 2B 组。目前有三组用于检测食品中赭曲霉素的分析方法：色谱法、ELISA 免疫测定法和化学传感器。此外，在谷物和/或食品受到能够产生黄曲霉毒素的真菌污染的情况下，赭曲霉素是黄曲霉毒素 B 的前体。赭曲霉素和黄曲霉毒素 B 的化学结构相似。这些真菌毒素是动物和谷物的病原体，对生物技术以及农业和食品工业产生重大的经济影响。本综述总结了与赭曲霉素相关的不同方面，如生物合成、毒理学研究以及其测定的分析方法。
