深海来源的抗生素安莎环素衍生物。

Antibiotic angucycline derivatives from the deepsea-derived .

机构信息

Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.

Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, China.

出版信息

Nat Prod Res. 2020 Dec;34(24):3444-3450. doi: 10.1080/14786419.2019.1577835. Epub 2019 Mar 5.

DOI:10.1080/14786419.2019.1577835

PMID:30835571

Abstract

A new (, grincamycin L) and two known ( and ) angucycline derivatives were obtained from the fermentation of deepsea-derived OUCT16-27 strain. The structures of - were elucidated based on the LC-MS analysis together with 1D and 2D NMR data assignment. In the antibacterial assay, and exhibited moderate growth inhibitions against multi-drug resistant (MDR) strains of , and with the minimum inhibitory concentrations (MICs) of 3.12-6.25 µg/mL.

摘要

从深海来源的 OUCT16-27 菌株的发酵中获得了一种新的（，grincamycin L）和两种已知的（和）angucycline 衍生物。基于 LC-MS 分析以及 1D 和 2D NMR 数据归属，确定了 - 的结构。在抗菌测定中，和对多药耐药（MDR）菌株、和表现出中等的生长抑制作用，最低抑菌浓度（MIC）为 3.12-6.25μg/ml。