School of Communication, Kookmin University, Bugak Hall 603, 77 Jeongneung-ro, Seongbuk-gu, Seoul 02707, Korea.
Department of Neurology, Kangdong Sacred Heart Hospital, College of Medicine, Hallym University, Seoul 05355, Korea.
Int J Environ Res Public Health. 2018 May 28;15(6):1085. doi: 10.3390/ijerph15061085.
Recent studies have demonstrated that antidepressants could enhance functional recovery via neuroplasticity beyond solely treating depression. However, since Koreans typically show a greater aversion to seeking psychiatric care than citizens of Western countries, the number of antidepressant prescriptions is low. Through this study, we aim to identify the factors that lead to the prescription of antidepressants in subjects with acute ischemic stroke (AIS) in clinical practice. A total of 775 patients with ischemic stroke (IS) participated in this study from March 2010 to May 2013. We used binary logistic regression to find predictors for escitalopram prescriptions. To reveal predictors for short-term functional outcomes, we used an adjusted regression model using a propensity score. Among the 775 participants, 39 (5.03%) were prescribed escitalopram. The duration of hospital stay (odds ratio (OR) = 1.07; 95% confidence interval (CI) = 1.04⁻1.10) and the use of mechanical ventilation were significantly more closely related to escitalopram prescriptions as compared to non-escitalopram prescriptions (OR = 5.15; 95% CI = 1.53⁻17.40). The use of escitalopram, on the other hand, was not significantly associated with short-term functional outcomes (OR = 1.27; 95% CI = 0.50⁻3.25). Duration of hospital stay and use of mechanical ventilation were significantly related to escitalopram prescriptions.
最近的研究表明，抗抑郁药除了治疗抑郁症外，还可以通过神经可塑性增强功能恢复。然而，由于韩国人通常比西方国家的公民更不愿意寻求精神保健，因此抗抑郁药的处方数量较低。通过这项研究，我们旨在确定导致临床实践中急性缺血性中风（AIS）患者开具抗抑郁药的因素。共有 775 名缺血性中风（IS）患者参加了 2010 年 3 月至 2013 年 5 月的研究。我们使用二元逻辑回归分析来寻找抗抑郁药处方的预测因素。为了揭示短期功能结局的预测因素，我们使用倾向评分调整回归模型。在 775 名参与者中，有 39 名（5.03%）开了艾司西酞普兰。与非艾司西酞普兰相比，住院时间（优势比（OR）=1.07；95%置信区间（CI）=1.04-1.10）和使用机械通气与开艾司西酞普兰密切相关（OR=5.15；95%CI=1.53-17.40）。相比之下，使用艾司西酞普兰与短期功能结局无关（OR=1.27；95%CI=0.50-3.25）。住院时间和使用机械通气与艾司西酞普兰的处方显著相关。
