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比较棕榈油、富含生育三烯酚的组分和α-生育酚补充剂对老年人抗氧化水平的影响。

Comparing Palm Oil, Tocotrienol-Rich Fraction and α-Tocopherol Supplementation on the Antioxidant Levels of Older Adults.

作者信息

Nor Azman Nor Helwa Ezzah, Goon Jo Aan, Abdul Ghani Siti Madiani, Hamid Zalina, Wan Ngah Wan Zurinah

机构信息

Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, 56000 Kuala Lumpur, Malaysia.

Sime Darby Foods and Beverages Marketing Sdn. Bhd, 47301 Petaling Jaya, Selangor, Malaysia.

出版信息

Antioxidants (Basel). 2018 May 28;7(6):74. doi: 10.3390/antiox7060074.

DOI:10.3390/antiox7060074
PMID:29843393
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6025588/
Abstract

BACKGROUND

Tocotrienol and tocopherol are known to prevent numerous degenerative diseases. The aim of this study is to compare the effects of tocotrienol-rich fraction (TRF) with α-tocopherol (α-TF) on the antioxidant status of healthy individuals aged between 50 and 55 years.

METHODS

Volunteers were divided into groups receiving placebo ( = 23), α-TF ( = 24) and TRF ( = 24). Fasting venous blood samples were taken at baseline (0 month), 3 months and 6 months of supplementation for the determination of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities as well as for reduced glutathione (GSH) and oxidized glutathione (GSSG) concentrations.

RESULTS

CAT and GPx were unaffected by TRF and α-TF supplementations. SOD activity increased significantly after six months of TRF supplementation. Analysis by gender showed that only female subjects had significant increases in SOD and GPx activities after six months of TRF supplementation. GPx activity was also significantly higher in females compared to males after six months of TRF supplementation. The GSH/GSSG ratio increased significantly after six months of TRF and α-TF supplementation in only the female subjects.

CONCLUSION

TRF and α-TF supplementation exhibited similar effects to the antioxidant levels of older adults with TRF having more significant effects in females.

摘要

背景

已知生育三烯酚和生育酚可预防多种退行性疾病。本研究的目的是比较富含生育三烯酚的组分（TRF）与α-生育酚（α-TF）对50至55岁健康个体抗氧化状态的影响。

方法

将志愿者分为接受安慰剂组（n = 23）、α-TF组（n = 24）和TRF组（n = 24）。在补充剂服用的基线期（0个月）、3个月和6个月时采集空腹静脉血样，以测定超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx）的活性以及还原型谷胱甘肽（GSH）和氧化型谷胱甘肽（GSSG）的浓度。

结果

TRF和α-TF补充剂对CAT和GPx没有影响。补充TRF六个月后，SOD活性显著增加。按性别分析表明，仅女性受试者在补充TRF六个月后SOD和GPx活性显著增加。补充TRF六个月后，女性的GPx活性也显著高于男性。仅在女性受试者中，补充TRF和α-TF六个月后，GSH/GSSG比值显著增加。

结论

补充TRF和α-TF对老年人的抗氧化水平表现出相似的影响，TRF对女性的影响更为显著。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/202c/6025588/ae07dcfbeed4/antioxidants-07-00074-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/202c/6025588/649782de7b1f/antioxidants-07-00074-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/202c/6025588/72fb98783891/antioxidants-07-00074-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/202c/6025588/3685dbd73c20/antioxidants-07-00074-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/202c/6025588/8b97cddbb62b/antioxidants-07-00074-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/202c/6025588/c55930ab5975/antioxidants-07-00074-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/202c/6025588/ed716456fc02/antioxidants-07-00074-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/202c/6025588/50caa3dbf97b/antioxidants-07-00074-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/202c/6025588/bf2980d85e4a/antioxidants-07-00074-g011.jpg
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