Protein Resources Laboratory, Food and Nutrition Department, Faculty of Food Engineering, University of Campinas (UNICAMP), Campinas 13083-862 São Paulo, Brazil.
School of Health Sciences, Federal University of Grande Dourados, Dourados 79825-070, Mato Grosso do Sul, Brazil.
Nutrients. 2018 May 28;10(6):683. doi: 10.3390/nu10060683.
Interest in the heat shock proteins (HSPs), as a natural physiological toolkit of living organisms, has ranged from their chaperone function in nascent proteins to the remedial role following cell stress. As part of the defence system, HSPs guarantee cell tolerance against a variety of stressors, including exercise, oxidative stress, hyper and hypothermia, hyper and hypoxia and improper diets. For the past couple of decades, research on functional foods has revealed a number of substances likely to trigger cell protection through mechanisms that involve the induction of HSP expression. This review will summarize the occurrence of the most easily inducible HSPs and describe the effects of dietary proteins, peptides, amino acids, probiotics, high-fat diets and other food-derived substances reported to induce HSP response in animals and humans studies. Future research may clarify the mechanisms and explore the usefulness of this natural alternative of defense and the modulating mechanism of each substance.
人们对热休克蛋白（HSPs）的兴趣，源于其作为生物体天然生理工具包的功能，涵盖了新生蛋白质的伴侣功能以及细胞应激后的修复功能。作为防御系统的一部分，HSP 可确保细胞耐受各种应激源，包括运动、氧化应激、高/低温、高/低氧和不当饮食。在过去的几十年中，对功能性食品的研究揭示了许多可能通过涉及诱导 HSP 表达的机制引发细胞保护的物质。本文综述了最容易诱导的 HSP 的发生，并描述了膳食蛋白质、肽、氨基酸、益生菌、高脂肪饮食和其他源自食物的物质在动物和人类研究中诱导 HSP 反应的作用。未来的研究可能会阐明这些机制，并探索这种天然防御替代物的有用性以及每种物质的调节机制。
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