Nogay Nalan Hakime
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J Pediatr Endocrinol Metab. 2017 Aug 28;30(9):947-955. doi: 10.1515/jpem-2016-0479.
Most of the studies investigating the correlation between the atherogenic index of plasma (AIP) and cardiometabolic risk factors have been conducted with adults, while only a limited number of related studies that involved children and adolescents has been conducted. The purpose of this study is to assess the correlation between the AIP and other cardiometabolic risk factors in adolescents.
This study was conducted with 310 girls and 90 boys who were between the ages of 6 and 18 years. After a 10-h fasting period, the biochemical values of the participants were measured in the morning. The anthropometric measurements of the participants were also taken. The AIP was calculated as Log10 (triglycerides/high density lipoprotein-cholesterol; TG/HDL-C).
In adolescents between the ages of 12 and 18, the mean AIP of the group with TG ≥130 mg/dL was significantly higher than that of the groups with TG of 90-129 mg/dL and <90 mg/dL. There was a strong correlation between TG and AIP for both boys and girls among the children and adolescents, while there was a strong correlation between the TG/HDL-C ratio and TG only in the boys who were within the 6-11-year-old age group.
An increase in AIP is associated with cardiovascular risk factors in children and adolescents other than those seen in adults. Based on the TG/HDL-C ratio, the AIP may be superior as a complementary index in the assessment of cardiometabolic risks in children and adolescents.
大多数研究血浆致动脉粥样硬化指数（AIP）与心脏代谢危险因素之间相关性的研究都是在成年人中进行的，而涉及儿童和青少年的相关研究数量有限。本研究的目的是评估青少年中AIP与其他心脏代谢危险因素之间的相关性。
本研究对310名6至18岁的女孩和90名男孩进行。在禁食10小时后，于早晨测量参与者的生化指标。还对参与者进行了人体测量。AIP的计算方法为Log10（甘油三酯/高密度脂蛋白胆固醇；TG/HDL-C）。
在12至18岁的青少年中，TG≥130mg/dL组的平均AIP显著高于TG为90-129mg/dL组和<90mg/dL组。在儿童和青少年中，男孩和女孩的TG与AIP之间均存在强相关性，而仅在6至11岁年龄组的男孩中，TG/HDL-C比值与TG之间存在强相关性。
AIP升高与儿童和青少年的心血管危险因素相关，这与成人中所见的情况不同。基于TG/HDL-C比值，AIP在评估儿童和青少年心脏代谢风险方面可能是一种更优的补充指标。
