甘油三酯与高密度脂蛋白胆固醇比值及甘油三酯-葡萄糖指数与动脉僵硬度风险的剂量反应关系。

Dose-response associations of triglyceride to high-density lipoprotein cholesterol ratio and triglyceride-glucose index with arterial stiffness risk.

机构信息

Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.

Department of Social Medicine and Health Management, College of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, People's Republic of China.

出版信息

Lipids Health Dis. 2024 Apr 20;23(1):115. doi: 10.1186/s12944-024-02095-z.

DOI:10.1186/s12944-024-02095-z

PMID:38643148

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11031917/

Abstract

BACKGROUND

The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and triglyceride-glucose (TyG) index are novel indexes for insulin resistance (IR). We aimed to evaluate associations of TG/HDL-C and TyG with arterial stiffness risk.

METHODS

We enrolled 1979 participants from the Rural Chinese Cohort Study, examining arterial stiffness by brachial-ankle pulse wave velocity (baPWV). Logistic and linear regression models were employed to calculate effect estimates. For meta-analysis, we searched relevant articles from PubMed, Embase and Web of Science up to August 26, 2023. The fixed-effects or random-effects models were used to calculate the pooled estimates. We evaluated dose-response associations using restricted cubic splines.

RESULTS

For cross-sectional studies, the adjusted ORs (95%CIs) for arterial stiffness were 1.12 (1.01-1.23) and 1.78 (1.38-2.30) for per 1 unit increment in TG/HDL-C and TyG. In the meta-analysis, the pooled ORs (95% CIs) were 1.26 (1.14-1.39) and 1.57 (1.36-1.82) for per 1 unit increment of TG/HDL-C and TyG. Additionally, both TG/HDL-C and TyG were positively related to PWV, with β of 0.09 (95% CI 0.04-0.14) and 0.57 (95% CI 0.35-0.78) m/s. We also found linear associations of TG/HDL-C and TyG with arterial stiffness risk.

CONCLUSIONS

High TG/HDL-C and TyG were related to increased arterial stiffness risk, indicating TG/HDL-C and TyG may be convincing predictors of arterial stiffness.

摘要

背景

甘油三酯与高密度脂蛋白胆固醇（TG/HDL-C）比值和甘油三酯-葡萄糖（TyG）指数是胰岛素抵抗（IR）的新指标。我们旨在评估 TG/HDL-C 和 TyG 与动脉僵硬风险的相关性。

方法

我们从农村中国队列研究中招募了 1979 名参与者，通过肱踝脉搏波速度（baPWV）检测动脉僵硬。采用逻辑回归和线性回归模型计算效应估计值。对于荟萃分析，我们从 PubMed、Embase 和 Web of Science 中检索了截至 2023 年 8 月 26 日的相关文章。使用固定效应或随机效应模型计算汇总估计值。我们使用限制性立方样条评估剂量-反应关系。

结果

对于横断面研究，每增加 1 个单位的 TG/HDL-C 和 TyG，动脉僵硬的调整后比值比（95%CI）分别为 1.12（1.01-1.23）和 1.78（1.38-2.30）。荟萃分析中，每增加 1 个单位的 TG/HDL-C 和 TyG，汇总比值比（95%CI）分别为 1.26（1.14-1.39）和 1.57（1.36-1.82）。此外，TG/HDL-C 和 TyG 均与 PWV 呈正相关，β值分别为 0.09（95%CI 0.04-0.14）和 0.57（95%CI 0.35-0.78）m/s。我们还发现 TG/HDL-C 和 TyG 与动脉僵硬风险呈线性关系。