School of Optometry and Vision Science, Queensland University of Technology, Brisbane, Queensland, Australia.
Sci Rep. 2018 May 29;8(1):8200. doi: 10.1038/s41598-018-26635-7.
Ambient light exposure is one environmental factor thought to play a role in the regulation of eye growth and refractive error development, and choroidal thickness changes have also been linked to longer term changes in eye growth. Therefore in this study we aimed to examine the influence of a 1-week period of morning light therapy upon choroidal thickness. Twenty two healthy young adult subjects had a series of macular choroidal thickness measurements collected with spectral domain optical coherence tomography before, and then following a 7-day period of increased daily light exposure. Increased light exposure was delivered through the use of commercially available light therapy glasses, worn for 30 minutes in the morning each day. A significant increase in subfoveal choroidal thickness (mean increase of +5.4 ± 10.3 µm) was found following 7-days of increased daily light exposure (p = 0.02). An increase in choroidal thickness was also observed associated with light therapy across the central 5 mm macular region. This study provides the first evidence in the human eye that daily morning light therapy results in small magnitude but statistically significant increases in choroidal thickness. These changes may have implications for our understanding of the impact of environmental factors upon eye growth.
环境光暴露被认为是调节眼球生长和屈光不正发展的因素之一，脉络膜厚度的变化也与眼球生长的长期变化有关。因此，在这项研究中，我们旨在研究一周的晨光疗法对脉络膜厚度的影响。22 名健康的年轻成年受试者使用谱域光学相干断层扫描（SD-OCT）在增加每日光照暴露前和暴露 7 天后，对黄斑脉络膜厚度进行了一系列测量。通过使用市售的光疗眼镜来增加光照，每天早上在户外戴 30 分钟。在增加每日光照暴露 7 天后，发现中心凹下脉络膜厚度（增加 5.4±10.3µm）显著增加（p=0.02）。在中央 5mm 黄斑区域，光疗也观察到脉络膜厚度的增加。这项研究首次在人类眼中提供了证据，表明每日晨光是导致脉络膜厚度小幅度但具有统计学意义的增加的原因。这些变化可能对我们理解环境因素对眼球生长的影响具有重要意义。
