Morimoto T, Jikkoh A, Yokoo N, Taki Y, Tanaka J, Kamiyama Y, Ozawa K, Tobe T
Life Sci. 1985 Apr 22;36(16):1577-80. doi: 10.1016/0024-3205(85)90382-0.
In the cirrhotic rat liver induced by carbon tetrachloride and phenobarbitone, the concentrations of mitochondrial Coenzyme Q were measured in comparison with other respiratory components. The concentration of cytochrome a(+a3) and Coenzyme Q significantly increased in the cirrhotic liver, without any changes in the ratio of Coenzyme Q to cytochrome a(+a3). It is suggested that such increase of Coenzyme Q plays an important role as one of the adaptive responses to compensate for the prolonged metabolic overload on the mitochondrial respiratory assembly. Also, from the findings that the concentrations of cytochrome a(+a3) in the mitochondria of cirrhotic liver increase concomitant with the severity of cirrhosis, it is suggested that the rise of Coenzyme Q levels may be one of the indicators for the decreased functional reserve capacity in liver cirrhosis.
在由四氯化碳和苯巴比妥诱导的肝硬化大鼠肝脏中，测定了线粒体辅酶Q的浓度，并与其他呼吸成分进行了比较。肝硬化肝脏中细胞色素a（+a3）和辅酶Q的浓度显著增加，而辅酶Q与细胞色素a（+a3）的比值没有任何变化。这表明辅酶Q的这种增加作为一种适应性反应，对补偿线粒体呼吸装置长期的代谢过载起着重要作用。此外，从肝硬化肝脏线粒体中细胞色素a（+a3）的浓度随肝硬化严重程度增加而增加的研究结果来看，提示辅酶Q水平的升高可能是肝硬化肝功能储备能力下降的指标之一。
