Kim Jong Youl, Park Joohyun, Chang Ji Young, Kim Sa-Hyun, Lee Jong Eun
Department of Anatomy, Yonsei University College of Medicine, Seoul 03722, Korea.
Department of Anatomy, Yonsei University College of Medicine, Seoul 03722, Korea.; Bk21 Plus Project for Medical Sciences and Brain Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea.
Exp Neurobiol. 2016 Oct;25(5):241-251. doi: 10.5607/en.2016.25.5.241. Epub 2016 Oct 26.
The immune response after stroke is known to play a major role in ischemic brain pathobiology. The inflammatory signals released by immune mediators activated by brain injury sets off a complex series of biochemical and molecular events which have been increasingly recognized as a key contributor to neuronal cell death. The primary immune mediators involved are glial cells and infiltrating leukocytes, including neutrophils, monocytes and lymphocyte. After ischemic stroke, activation of glial cells and subsequent release of pro- and anti-inflammatory signals are important for modulating both neuronal cell damage and wound healing. Infiltrated leukocytes release inflammatory mediators into the site of the lesion, thereby exacerbating brain injury. This review describes how the roles of glial cells and circulating leukocytes are a double-edged sword for neuroinflammation by focusing on their detrimental and protective effects in ischemic stroke. Here, we will focus on underlying characterize of glial cells and leukocytes under inflammation after ischemic stroke.
已知中风后的免疫反应在缺血性脑病理生物学中起主要作用。脑损伤激活的免疫介质释放的炎症信号引发了一系列复杂的生化和分子事件，这些事件越来越被认为是神经元细胞死亡的关键因素。主要涉及的免疫介质是胶质细胞和浸润的白细胞，包括中性粒细胞、单核细胞和淋巴细胞。缺血性中风后，胶质细胞的激活以及随后促炎和抗炎信号的释放对于调节神经元细胞损伤和伤口愈合都很重要。浸润的白细胞将炎症介质释放到损伤部位，从而加剧脑损伤。本综述通过关注胶质细胞和循环白细胞在缺血性中风中的有害和保护作用，描述了它们在神经炎症中如何扮演双刃剑的角色。在这里，我们将重点关注缺血性中风后炎症状态下胶质细胞和白细胞的潜在特征。
