Xu Jingya, Zhao Weiming
Department of Biochemistry, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Brain Sci. 2025 Jun 4;15(6):605. doi: 10.3390/brainsci15060605.
Ischemic stroke (IS) is a disease characterized by disruption of blood flow to the brain, resulting in damage to brain tissue and neurological deficits. The high incidence of IS and the complexity of the underlying pathophysiology of IS have led to the need for further therapeutic development. It has been found that pericytes are indispensable multifunctional cells, which can coordinate multiple biological processes, and play a vital role in the development of IS. The purpose of this review is to provide a detailed overview of the role of pericytes in regulating vascular blood flow, maintaining BBB, regulating immune response, and promoting intracerebral fibrosis during the pathophysiological process after IS, which have dual effects on intracerebral recovery after IS. Finally, the article summarizes the current strategies targeting pericytes for the treatment of IS.
缺血性中风（IS）是一种以脑部血流中断为特征的疾病，会导致脑组织损伤和神经功能缺损。IS的高发病率以及其潜在病理生理学的复杂性导致了进一步治疗开发的需求。已发现周细胞是不可或缺的多功能细胞，其可协调多种生物学过程，并在IS的发展中起关键作用。本综述的目的是详细概述周细胞在IS后病理生理过程中调节血管血流、维持血脑屏障、调节免疫反应以及促进脑内纤维化方面的作用，这些作用对IS后的脑内恢复具有双重影响。最后，本文总结了目前针对周细胞治疗IS的策略。
