School of Pharmaceutical Science & Technology, Tianjin Key Laboratory for Modern Drug Delivery & High Efficiency, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin 300072, China.
Biomater Sci. 2018 Jun 25;6(7):1712-1716. doi: 10.1039/c8bm00369f.
Nitroimidazole-bearing nanomedicine has been popular as a hypoxia-responsive platform for on-demand drug delivery. We report the singlet oxygen-responsive property of nitroimidazole-containing micelles and the corresponding reaction mechanism, which would pave the way for developing a dual hypoxia- and singlet oxygen-sensitive drug delivery nanoplatform based on a simple nitroimidazole moiety.
载有硝基咪唑的纳米医学因其作为缺氧响应平台用于按需药物输送而受到广泛关注。我们报告了含硝基咪唑胶束的单线态氧响应特性及其相应的反应机制，这将为基于简单硝基咪唑基团开发双缺氧和单线态氧敏感药物输送纳米平台铺平道路。
