可见光诱导的单线态氧介导的聚合物胶束细胞内解离，该聚合物胶束共负载有光敏剂和抗癌药物以增强光动力疗法。
Visible light-induced singlet oxygen-mediated intracellular disassembly of polymeric micelles co-loaded with a photosensitizer and an anticancer drug for enhanced photodynamic therapy.
作者信息
Saravanakumar Gurusamy, Lee Junseok, Kim Jihoon, Kim Won Jong
机构信息
Center for Self-assembly and Complexity, Institute of Basic Science (IBS), and Department of Chemistry, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
出版信息
Chem Commun (Camb). 2015 Jun 21;51(49):9995-8. doi: 10.1039/c5cc01937k.
Herein, we report a biocompatible amphiphilic block copolymer micelle bearing a singlet oxygen-sensitive vinyldithioether cleavable linker at the core-shell junction, which undergoes singlet oxygen-mediated photocleavage in the presence of visible light. The micelle facilitates the light-responsive release of singlet oxygen and an anticancer drug for enhanced photodynamic therapy.
在此，我们报道了一种生物相容性两亲性嵌段共聚物胶束，其在核壳交界处带有单重态氧敏感的乙烯基二硫醚可裂解连接基，在可见光存在下会发生单重态氧介导的光裂解。该胶束有助于单重态氧和抗癌药物的光响应释放，以增强光动力疗法。
Zotero 插件