González-Reimers Emilio, Romero-Acevedo Lucía, Espelosín-Ortega Elisa, Martín-González M Candelaria, Quintero-Platt Geraldine, Abreu-González Pedro, José de-la-Vega-Prieto María, Martínez-Martínez Daniel, Santolaria-Fernández Francisco
Servicio de Medicina Interna, Universidad de La Laguna, Tenerife, Canary Islands, Spain.
Servicio de laboratorio, Universidad de La Laguna, Tenerife, Canary Islands, Spain.
Alcohol Alcohol. 2018 Sep 1;53(5):503-510. doi: 10.1093/alcalc/agy037.
Fibroblast growth factor (FGF-23) and α-Klotho (Klotho) levels may be altered in inflammatory conditions, possibly as compensatory mechanisms. Klotho exerts a protective effect on neurodegeneration and improves learning and cognition. No data exist about the association of Klotho and FGF-23 levels with brain atrophy observed in alcoholics. The aim of this study is to explore these relationships.
FGF-23 and Klotho levels are altered in inflammation, possibly as compensatory mechanisms. Klotho enhances learning, but its role in ethanol-mediated brain atrophy is unknown. We found higher FGF-23 and lower Klotho levels in 131 alcoholics compared with 41 controls. Among cirrhotics, Klotho was higher and inversely related to brain atrophy.
The study was performed on 131 alcoholic patients (54 cirrhotics) and 41 age- and sex-matched controls, in whom a brain computed tomography (CT) was performed and several indices were calculated.
Marked brain atrophy was observed among patients when compared with controls. Patients also showed higher FGF-23 and lower Klotho values. However, among cirrhotics, Klotho values were higher. Klotho was inversely related to brain atrophy (for instance, ventricular index (ρ = -0.23, P = 0.008)), especially in cirrhotics. Klotho was also directly related to tumor necrosis factor (TNF) alpha (ρ = 0.22; P = 0.026) and inversely to transforming growth factor (TGF)-β (ρ = -0.34; P = 0.002), but not to C-reactive protein (CRP) or malondialdehyde levels. FGF-23 was also higher among cirrhotics but showed no association with CT indices.
Klotho showed higher values among cirrhotics, and was inversely related to brain atrophy. FGF-23, although high among patients, especially cirrhotics, did not show any association with brain atrophy. Some inflammatory markers or cytokines, such as CRP or TGF-β were related to brain atrophy.
成纤维细胞生长因子（FGF - 23）和α-klotho（Klotho）水平在炎症状态下可能会发生改变，这可能是一种代偿机制。Klotho对神经退行性变具有保护作用，并能改善学习和认知能力。目前尚无关于酗酒者中Klotho和FGF - 23水平与脑萎缩之间关联的数据。本研究旨在探讨这些关系。
FGF - 23和Klotho水平在炎症中发生改变，可能是一种代偿机制。Klotho能增强学习能力，但其在乙醇介导的脑萎缩中的作用尚不清楚。我们发现131名酗酒者的FGF - 23水平较高，Klotho水平较低，而41名对照者则相反。在肝硬化患者中，Klotho水平较高，且与脑萎缩呈负相关。
本研究对131名酒精性患者（54名肝硬化患者）和41名年龄及性别匹配的对照者进行，对他们进行了脑部计算机断层扫描（CT）并计算了多个指标。
与对照组相比，患者中观察到明显的脑萎缩。患者还表现出较高的FGF - 23值和较低的Klotho值。然而，在肝硬化患者中，Klotho值较高。Klotho与脑萎缩呈负相关（例如，脑室指数（ρ = -0.23；P = 0.008）），尤其是在肝硬化患者中。Klotho还与肿瘤坏死因子（TNF）α呈正相关（ρ = 0.22；P = 0.026），与转化生长因子（TGF）-β呈负相关（ρ = -0.34；P = 0.002），但与C反应蛋白（CRP）或丙二醛水平无关。在肝硬化患者中FGF - 23也较高，但与CT指标无关联。
肝硬化患者中Klotho值较高，且与脑萎缩呈负相关。FGF - 23虽然在患者中尤其是肝硬化患者中较高，但与脑萎缩无任何关联。一些炎症标志物或细胞因子，如CRP或TGF -β与脑萎缩有关。
