Saldeen K, Christie N, Nelson W R, Movat H Z
Thromb Res. 1985 Jan 1;37(1):85-9. doi: 10.1016/0049-3848(85)90035-0.
A vasoactive peptide known to increase vascular permeability and corresponding to residues 30-43 of the human fibrinogen B beta-chain induced polymorphonuclear leukocyte emigration in rabbit skin in vivo. The leukocyte emigration was much stronger after 2 h than after 0.5 h. Addition of prostaglandin E2 (PGE2) did not influence the chemotactic activity, which might possibly be explained by a known PGI2 releasing capacity of this peptide. PGE2 enhanced the leukocyte emigration due to leukotriene B4.
一种已知可增加血管通透性且与人纤维蛋白原Bβ链30 - 43位残基相对应的血管活性肽，在体内可诱导兔皮肤中的多形核白细胞迁移。2小时后的白细胞迁移比0.5小时后强得多。添加前列腺素E2（PGE2）并不影响趋化活性，这可能是由于该肽已知具有释放前列环素（PGI2）的能力。PGE2可增强由白三烯B4引起的白细胞迁移。
