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相似文献

1
Leukotriene B4: a mediator of vascular permeability.白三烯B4：血管通透性的介质
Br J Pharmacol. 1981 Mar;72(3):483-6. doi: 10.1111/j.1476-5381.1981.tb11000.x.
2
Potentiation of bradykinin-induced vascular permeability increase by prostaglandin E2 and arachidonic acid in rabbit skin.前列腺素E2和花生四烯酸对缓激肽诱导的兔皮肤血管通透性增加的增强作用。
Prostaglandins. 1975 Nov;10(5):747-58. doi: 10.1016/0090-6980(75)90003-9.
3
Species difference in increased vascular permeability by synthetic leukotriene C4 and D4.合成白三烯C4和D4导致血管通透性增加的种属差异。
Prostaglandins. 1981 Apr;21(4):637-48. doi: 10.1016/0090-6980(81)90012-5.
4
Leukotriene B4: an inflammatory mediator with vascular actions in vivo.白三烯B4：一种在体内具有血管作用的炎症介质。
Agents Actions Suppl. 1982;11:51-61.
5
Prostaglandin E2, prostaglandin I2 and the vascular changes of inflammation.前列腺素E2、前列腺素I2与炎症的血管变化
Br J Pharmacol. 1979 Mar;65(3):517-24. doi: 10.1111/j.1476-5381.1979.tb07860.x.
6
Inflammatory oedema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability.降钙素基因相关肽（CGRP）与血管通透性增加介质之间协同作用诱导的炎性水肿。
Br J Pharmacol. 1985 Dec;86(4):855-60. doi: 10.1111/j.1476-5381.1985.tb11107.x.
7
[The mechanism of anti-vascular permeability of 2-(2-fluoro-4-biphenylyl) propionic acid(Flurbiprofen) (author's transl)].2-(2-氟-4-联苯基)丙酸（氟比洛芬）抗血管通透性的机制（作者译）
Nihon Yakurigaku Zasshi. 1980 Jan;76(1):45-9.
8
Isomers of leukotriene B4 possess different biological potencies.白三烯B4的异构体具有不同的生物活性。
Prostaglandins. 1981 Jan;21(1):143-52. doi: 10.1016/0090-6980(81)90204-5.
9
The inflammatory effects of hydroperoxy and hydroxy acid products of arachidonate lipoxygenase in rabbit skin.花生四烯酸脂氧合酶的氢过氧酸和羟酸产物对兔皮肤的炎症作用。
Br J Pharmacol. 1981 Oct;74(2):429-33. doi: 10.1111/j.1476-5381.1981.tb09988.x.
10
The in vivo effect of leukotriene B4 on polymorphonuclear leukocytes and the microcirculation. Comparison with activated complement (C5a des Arg) and enhancement by prostaglandin E2.白三烯B4对多形核白细胞及微循环的体内作用。与活化补体（C5a去精氨酸）的比较及前列腺素E2的增强作用。
Am J Pathol. 1984 May;115(2):233-44.

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Lipids in Liver Failure Syndromes: A Focus on Eicosanoids, Specialized Pro-Resolving Lipid Mediators and Lysophospholipids.肝衰竭综合征中的脂质：聚焦类二十烷酸、特异性促解决脂质介质和溶血磷脂。
Front Immunol. 2022 Mar 31;13:867261. doi: 10.3389/fimmu.2022.867261. eCollection 2022.
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Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases.花生四烯酸代谢产物与心血管和代谢疾病
Int J Mol Sci. 2018 Oct 23;19(11):3285. doi: 10.3390/ijms19113285.
3
Synopsis of arachidonic acid metabolism: A review.花生四烯酸代谢综述
J Adv Res. 2018 Mar 13;11:23-32. doi: 10.1016/j.jare.2018.03.005. eCollection 2018 May.
4
[Not Available].[无可用内容]
Doc Ophthalmol. 1984 May;57(3):215-262. doi: 10.1007/BF00143085.
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Eicosanoid storm in infection and inflammation.感染与炎症中的类花生酸风暴
Nat Rev Immunol. 2015 Aug;15(8):511-23. doi: 10.1038/nri3859. Epub 2015 Jul 3.
6
Low-dose aspirin (acetylsalicylate) prevents increases in brain PGE2, 15-epi-lipoxin A4 and 8-isoprostane concentrations in 9 month-old HIV-1 transgenic rats, a model for HIV-1 associated neurocognitive disorders.低剂量阿司匹林（乙酰水杨酸）可防止9月龄HIV-1转基因大鼠（一种HIV-1相关神经认知障碍模型）大脑中前列腺素E2、15-表-脂氧素A4和8-异前列腺素浓度升高。
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7
C1 esterase inhibitor reduces lower extremity ischemia/reperfusion injury and associated lung damage.C1 酯酶抑制剂可减轻下肢缺血/再灌注损伤及相关肺损伤。
PLoS One. 2013 Aug 26;8(8):e72059. doi: 10.1371/journal.pone.0072059. eCollection 2013.
8
Microvascular mechanisms of histamine-induced potentiation of leukocyte adhesion evoked by chemoattractants.组胺诱导趋化因子引起的白细胞黏附增强的微血管机制。
Br J Pharmacol. 1995 Dec;116(8):3175-80. doi: 10.1111/j.1476-5381.1995.tb15121.x.
9
Activation by Phoneutria nigriventer (armed spider) venom of tissue kallikrein-kininogen-kinin system in rabbit skin in vivo.黑腹栉足蛛（武装蜘蛛）毒液对家兔皮肤组织激肽释放酶-激肽原-激肽系统的体内激活作用。
Br J Pharmacol. 1993 Jun;109(2):539-43. doi: 10.1111/j.1476-5381.1993.tb13604.x.
10
Regulation of leukotriene biosynthesis.白三烯生物合成的调控
Cancer Metastasis Rev. 1994 Dec;13(3-4):257-67. doi: 10.1007/BF00666096.

本文引用的文献

1
Nomenclature for leukotrienes.白三烯的命名法。
Prostaglandins. 1980 May;19(5):645-8. doi: 10.1016/0090-6980(80)90099-4.
2
The regulation of human eosinophil function by endogenous mono-hydroxy-eicosatetraenoic acids (HETEs).内源性单羟基二十碳四烯酸（HETEs）对人类嗜酸性粒细胞功能的调节。
J Immunol. 1980 Feb;124(2):926-33.
3
Leukotriene A: stereochemistry and enzymatic conversion to leukotriene B.白三烯A：立体化学及向白三烯B的酶促转化
Biochem Biophys Res Commun. 1980 Feb 12;92(3):954-61. doi: 10.1016/0006-291x(80)90795-0.
4
Prostaglandins as potentiators of increased vascular permeability in inflammation.前列腺素作为炎症中血管通透性增加的增强剂。
Nature. 1973 Nov 23;246(5430):215-7. doi: 10.1038/246215a0.
5
Role of prostaglandin-mediated vasodilatation in inflammation.前列腺素介导的血管舒张在炎症中的作用。
Nature. 1977 Dec 8;270(5637):530-2. doi: 10.1038/270530a0.
6
Metabolism of arachidonic acid in polymorphonuclear leukocytes. Structural analysis of novel hydroxylated compounds.多形核白细胞中花生四烯酸的代谢。新型羟基化化合物的结构分析。
J Biol Chem. 1979 Aug 25;254(16):7865-9.
7
Arachidonic acid metabolism in polymorphonuclear leukocytes: effects of ionophore A23187.多形核白细胞中的花生四烯酸代谢：离子载体A23187的作用。
Proc Natl Acad Sci U S A. 1979 May;76(5):2148-52. doi: 10.1073/pnas.76.5.2148.
8
Prostaglandin E2, prostaglandin I2 and the vascular changes of inflammation.前列腺素E2、前列腺素I2与炎症的血管变化
Br J Pharmacol. 1979 Mar;65(3):517-24. doi: 10.1111/j.1476-5381.1979.tb07860.x.
9
PGI2: a potential mediator of inflammation.前列环素2：一种潜在的炎症介质。
Prostaglandins. 1978 Aug;16(2):253-8. doi: 10.1016/0090-6980(78)90027-8.
10
Slow-reacting substance of anaphylaxis: studies on purification and characterisation.过敏反应迟缓反应物质：纯化与特性研究
Agents Actions Suppl. 1979(6):27-36. doi: 10.1007/978-3-0348-7232-4_3.

白三烯B4：血管通透性的介质

Leukotriene B4: a mediator of vascular permeability.

作者信息

Bray M A, Cunningham F M, Ford-Hutchinson A W, Smith M J

出版信息

Br J Pharmacol. 1981 Mar;72(3):483-6. doi: 10.1111/j.1476-5381.1981.tb11000.x.

DOI:10.1111/j.1476-5381.1981.tb11000.x
PMID:6266567
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2071580/
Abstract

1 Intradermal injection of leukotriene B4 (LTB4) or prostaglandin E2 (PGE2), 1 to 100 ng per skin site produced little or no change in plasma exudation in the rabbit, guinea-pig and rat. 2 Intradermal injection of LTB4 or PGE2 together with bradykinin (500 ng) resulted in a significant potentiation of the plasma exudation produced by bradykinin alone in the rabbit and guinea-pig. 4 LTB4 (1 to 10 ng) had no effect on blood flow in the rabbit skin, in contrast to PGE2 which was a potent vasodilator in this species. 5 It is concluded that LTB4 is a mediator of vascular permeability and that this effect can only be observed in the presence of a vasodilator such as PGE2.

摘要
  1. 在兔、豚鼠和大鼠的每个皮肤部位皮内注射白三烯B4（LTB4）或前列腺素E2（PGE2）1至100纳克，对血浆渗出几乎没有影响或没有影响。2. 在兔和豚鼠中，将LTB4或PGE2与缓激肽（500纳克）一起皮内注射，会使缓激肽单独引起的血浆渗出显著增强。4. 与PGE2（该物种中的一种强效血管舒张剂）不同，LTB4（1至10纳克）对兔皮肤血流没有影响。5. 得出的结论是，LTB4是血管通透性的介质，并且只有在存在诸如PGE2之类的血管舒张剂的情况下才能观察到这种作用。