白三烯B4：血管通透性的介质
Leukotriene B4: a mediator of vascular permeability.
作者信息
Bray M A, Cunningham F M, Ford-Hutchinson A W, Smith M J
出版信息
Br J Pharmacol. 1981 Mar;72(3):483-6. doi: 10.1111/j.1476-5381.1981.tb11000.x.
Abstract
1 Intradermal injection of leukotriene B4 (LTB4) or prostaglandin E2 (PGE2), 1 to 100 ng per skin site produced little or no change in plasma exudation in the rabbit, guinea-pig and rat. 2 Intradermal injection of LTB4 or PGE2 together with bradykinin (500 ng) resulted in a significant potentiation of the plasma exudation produced by bradykinin alone in the rabbit and guinea-pig. 4 LTB4 (1 to 10 ng) had no effect on blood flow in the rabbit skin, in contrast to PGE2 which was a potent vasodilator in this species. 5 It is concluded that LTB4 is a mediator of vascular permeability and that this effect can only be observed in the presence of a vasodilator such as PGE2.
摘要
- 在兔、豚鼠和大鼠的每个皮肤部位皮内注射白三烯B4（LTB4）或前列腺素E2（PGE2）1至100纳克，对血浆渗出几乎没有影响或没有影响。2. 在兔和豚鼠中，将LTB4或PGE2与缓激肽（500纳克）一起皮内注射，会使缓激肽单独引起的血浆渗出显著增强。4. 与PGE2（该物种中的一种强效血管舒张剂）不同，LTB4（1至10纳克）对兔皮肤血流没有影响。5. 得出的结论是，LTB4是血管通透性的介质，并且只有在存在诸如PGE2之类的血管舒张剂的情况下才能观察到这种作用。
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