Cimmino Alessio, Maddau Lucia, Masi Marco, Linaldeddu Benedetto Teodoro, Evidente Antonio
a Dipartmento di Scienze Chimiche , Università di Napoli Federico II, Complesso Universitario Monte S. Angelo , Napoli , Italy.
b Dipartimento di Agraria , Sezione di Patologia Vegetale ed Entomologia, Università degli Studi di Sassari , Sassari , Italy.
Nat Prod Res. 2019 Jul;33(13):1862-1869. doi: 10.1080/14786419.2018.1477154. Epub 2018 May 30.
In this study the production of secondary metabolites by a virulent strain of , a recently described pathogen originally found on declining European hackberry trees in Italy, was investigated for the first time. Chemical analysis of the culture filtrate extracts led to the isolation of three well known compounds as -(-)-mellein and (3,4)-and (3,4)-4-hydroxy melleins which were identified by spectroscopic methods (essentially NMR and ESIMS). The isolated compounds were tested for their phytotoxic, antifungal and zootoxic activities. Among them, only -(-)-mellein was found to be active.
在本研究中，首次对一种毒性菌株产生次生代谢产物的情况进行了调查，该菌株是一种最近描述的病原体，最初在意大利日渐衰败的欧洲朴树上被发现。对培养滤液提取物进行化学分析后，分离出了三种知名化合物，即(-)-水芹烯和(3,4)-以及(3,4)-4-羟基水芹烯，这些化合物通过光谱方法（主要是核磁共振和电喷雾离子化质谱）进行了鉴定。对分离出的化合物进行了植物毒性、抗真菌和动物毒性活性测试。其中，仅发现(-)-水芹烯具有活性。
