Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University , Guangzhou , China.
Nat Prod Res. 2019 Dec;33(23):3378-3382. doi: 10.1080/14786419.2018.1478830. Epub 2018 May 30.
Three new lignanamides, that is, a new lignanamide (), and a pair of enantiomers ( and ) were isolated from the EtOAc-soluble fraction of an EtOH extract of the root of . The structures of these new compounds, including their absolute configuration, were established on the basis of HR-ESI-MS, NMR spectroscopic data and quantum chemical ECD calculations. Compound showed significant anti-inflammatory activity in LPS-induced RAW 264.7 macrophages with the IC value of 10.77 ± 2.14 μM, comparing to that of positive control quercetin (17.21 ± 0.50 μM).
从 的根的 EtOH 提取物的 EtOAc 可溶部分分离得到三种新的木脂酰胺，即一种新的木脂酰胺（）和一对对映异构体（和）。这些新化合物的结构，包括它们的绝对构型，是基于高分辨电喷雾电离质谱（HR-ESI-MS）、NMR 波谱数据和量子化学ECD 计算确定的。化合物在 LPS 诱导的 RAW 264.7 巨噬细胞中显示出显著的抗炎活性，IC 值为 10.77±2.14 μM，与阳性对照槲皮素（17.21±0.50 μM）相比。
