Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, China.
Nat Prod Res. 2021 Feb;35(3):447-454. doi: 10.1080/14786419.2019.1636375. Epub 2019 Jul 8.
Lyciyunin, a new dimer of feruloyltyramine (), together with five known tyramines (), was isolated from the water-soluble fraction of an EtOH extract of the root of . Based on HR-TOF-MS, NMR spectral data and quantum chemistry ECD calculations, the structure of this new compound was determined, including its absolute configuration. Compounds () were tested for their antioxidant activity using DPPH radical scavenging assay, and showed the moderate antioxidant activities with IC values of 12.44 ± 0.39, 21.29 ± 0.75, 24.44 ± 1.63, 21.15 ± 0.66, 21.15 ± 0.66 and 45.15 ± 0.56 μM, respectively. Compounds () showed anti-inflammatory activity in LPS-induced RAW 264.7 macrophages with the IC values of 43.95 ± 6.11 and 33.50 ± 2.04 μM, respectively.
从地榆水提物的醇溶性部分中分离得到一个新的二聚体化合物 Lyciyunin（），它由阿魏酰酪胺（）和五个已知的酪胺类化合物（）组成。根据高分辨飞行时间质谱（HR-TOF-MS）、NMR 波谱数据和量子化学ECD 计算，确定了该新化合物的结构，包括其绝对构型。采用 DPPH 自由基清除实验测试化合物（）的抗氧化活性，结果表明化合物（）具有中等的抗氧化活性，IC值分别为 12.44±0.39、21.29±0.75、24.44±1.63、21.15±0.66、21.15±0.66 和 45.15±0.56μM。化合物（）在 LPS 诱导的 RAW 264.7 巨噬细胞中表现出抗炎活性，IC 值分别为 43.95±6.11 和 33.50±2.04μM。
