Bylund William, Delahanty Liam, Cooper Maxwell
Department of Emergency Medicine, Naval Medical Center Portsmouth, Portsmouth, Virginia.
Clin Pract Cases Emerg Med. 2017 Oct 3;1(4):323-325. doi: 10.5811/cpcem.2017.7.34405. eCollection 2017 Nov.
Ketamine is often used for pediatric procedural sedation due to low rates of complications, with allergic reactions being rare. Immediately following intramuscular (IM) ketamine administration, a three-year-old female rapidly developed facial edema and diffuse urticarial rash, with associated wheezing and oxygen desaturation. Symptoms resolved following treatment with epinephrine, dexamethasone and diphenhydramine. This case presents a clinical reaction to ketamine consistent with anaphylaxis due to histamine release, but it is uncertain whether this was immunoglobulin E mediated. This is the only case reported to date of allergic reaction to IM ketamine, without co-administration of other agents.
由于并发症发生率低，氯胺酮常用于儿科手术镇静，过敏反应很少见。在肌肉注射氯胺酮后，一名三岁女性迅速出现面部水肿和弥漫性荨麻疹皮疹，并伴有喘息和氧饱和度下降。经肾上腺素、地塞米松和苯海拉明治疗后症状缓解。该病例呈现出因组胺释放导致的与过敏反应相符的氯胺酮临床反应，但尚不确定这是否由免疫球蛋白E介导。这是迄今为止报道的唯一一例对肌肉注射氯胺酮过敏反应的病例，且未同时使用其他药物。
