Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600025, India.
Department of Biochemistry, School of Biological Sciences, Chungbuk National University, Cheongju 28644, Republic of Korea.
Oxid Med Cell Longev. 2018 Apr 19;2018:5241524. doi: 10.1155/2018/5241524. eCollection 2018.
Serine-threonine kinase receptor-associated protein (STRAP) is a transforming growth factor (TGF-) receptor-interacting protein that has been implicated in both cell proliferation and cell death in response to various stresses. However, the precise roles of STRAP in these cellular processes are still unclear. The mechanisms by which STRAP controls both cell proliferation and cell death are now beginning to be unraveled. In addition to its biological roles, this review also focuses on the dual functions of STRAP in cancers displaying redox dysregulation, where it can behave as a tumor suppressor or an oncogene (i.e., it can either inhibit or promote tumor formation), depending on the cellular context. Further studies are needed to define the functions of STRAP and the redox-sensitive intracellular signaling pathways that enhance either cell proliferation or cell death in human cancer tissues, which may help in the development of effective treatments for cancer.
丝氨酸-苏氨酸激酶受体相关蛋白（STRAP）是一种转化生长因子-β（TGF-β）受体相互作用蛋白，已被牵连到各种应激下的细胞增殖和细胞死亡中。然而，STRAP 在这些细胞过程中的确切作用仍不清楚。STRAP 控制细胞增殖和细胞死亡的机制现在开始被揭示。除了其生物学作用外，本综述还重点关注了在表现出氧化还原失调的癌症中 STRAP 的双重功能，根据细胞环境，它可以作为肿瘤抑制因子或癌基因（即，它可以抑制或促进肿瘤形成）。需要进一步的研究来定义 STRAP 的功能和氧化还原敏感的细胞内信号通路，这些信号通路可以增强人类癌症组织中的细胞增殖或细胞死亡，这可能有助于开发有效的癌症治疗方法。
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