Joo Hyun-Chel, Youn Young-Nam, Chang Byung-Chul, Yoo Kyung-Jong
Division of Cardiovascular Surgery, Department of Thoracic and Cardiovascular Surgery, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.
J Thorac Dis. 2018 Apr;10(4):2268-2278. doi: 10.21037/jtd.2018.03.190.
The efficacy and safety of off-pump coronary artery bypass grafting (OPCAB) in emergency revascularization remains controversial despite its widespread use. The aim of our study was to examine the applicability and safety of OPCAB in patients who were indicated for emergency surgery.
This single-center study reviewed the indication, operative data, and early and long-term outcomes of 113 patients (mean age, 67.2±9.0 years; logistic EuroSCORE, 14.3±13.5) who underwent emergency OPCAB from January 2003 to December 2014 and were followed up (94.6% completion rate) for a mean 51.1±40.3 (range, 1-135) months.
Emergency OPCAB was associated with favorable surgical outcomes (number of distal anastomoses per patient, 3.04±0.87; internal thoracic artery (IMA) use, 98.2%; complete revascularization, 79.6%) and in-hospital outcomes (mortality, 5.3%; low cardiac output syndrome, 5.3%; stroke, 2.7%; pulmonary complications, 8.8%; renal failure, 11.5%). Only five patients (4.4%) required on-pump conversion. The 10-year outcomes were also acceptable (survival, 75.4%±5.6%; major cerebral and cardiovascular events, 52.1%±1.8%). The multivariate risk factors for late mortality were peripheral vascular disease (HR 2.95, 95% CI: 1.11-11.83), cardiogenic shock (HR 3.67, 95% CI: 1.35-9.96), and incomplete revascularization (HR 3.41, 95% CI: 1.06-14.26). When patients were separated by whether the procedure was performed early (<2010) or late (≥2010) in the study period, the late period cohort had better outcomes despite containing higher-risk patients.
Our study suggests that emergency OPCAB can be performed safely and effectively with good hospital outcomes and adequate long-term results. OPCAB strategy can be considered as a good option in emergency revascularization.
尽管非体外循环冠状动脉旁路移植术(OPCAB)已被广泛应用,但其在急诊血运重建中的有效性和安全性仍存在争议。我们研究的目的是探讨OPCAB在需要急诊手术患者中的适用性和安全性。
这项单中心研究回顾了2003年1月至2014年12月期间接受急诊OPCAB的113例患者(平均年龄67.2±9.0岁;欧洲心脏手术风险评估系统(EuroSCORE)逻辑评分14.3±13.5)的手术指征、手术数据以及早期和长期预后,并进行了随访(随访完成率94.6%),平均随访时间为51.1±40.3(范围1 - 135)个月。
急诊OPCAB具有良好的手术效果(每位患者的远端吻合口数量为3.04±0.87;胸廓内动脉(IMA)使用率为98.2%;完全血运重建率为79.6%)和住院期间预后(死亡率5.3%;低心排血量综合征5.3%;卒中2.7%;肺部并发症8.8%;肾衰竭11.5%)。仅5例患者(4.4%)需要转为体外循环手术。10年预后也可接受(生存率75.4%±5.6%;主要心脑血管事件52.1%±1.8%)。晚期死亡的多因素风险因素为外周血管疾病(HR 2.95,95% CI:1.11 - 11.83)、心源性休克(HR 3.67,95% CI:1.35 - 9.96)和血运重建不完全(HR 3.41,95% CI:1.06 - 14.26)。当根据研究期间手术时间早(<2010年)或晚(≥2010年)对患者进行分组时,尽管晚期队列中患者风险较高,但其预后更好。
我们的研究表明,急诊OPCAB可以安全有效地进行,具有良好的住院效果和足够的长期结果。OPCAB策略可被视为急诊血运重建的一个良好选择。