α1-去甲肾上腺素能受体阻断降低豚鼠下丘脑和视前区的核雌激素受体结合。
Alpha 1-noradrenergic receptor blockade decreases nuclear estrogen receptor binding in guinea pig hypothalamus and preoptic area.
作者信息
Clark A S, Nock B, Feder H H, Roy E J
出版信息
Brain Res. 1985 Mar 18;330(1):197-9. doi: 10.1016/0006-8993(85)90028-9.
PMID:2985191
Abstract
Prazosin, a putative alpha 1-noradrenergic antagonist, reduced nuclear estrogen receptor levels in the hypothalamus and preoptic area of the estrogen-primed guinea pig. Noradrenergic transmission may alter steroid-dependent processes and neuroendocrine function through actions on steroid-concentrating cells.
摘要
哌唑嗪，一种假定的α1-去甲肾上腺素能拮抗剂，降低了雌激素预处理的豚鼠下丘脑和视前区的核雌激素受体水平。去甲肾上腺素能传递可能通过作用于类固醇浓缩细胞来改变类固醇依赖的过程和神经内分泌功能。
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