Johnson A E, Renner K J, Allen D, Luine V N, Nock B, Feder H H
Brain Res. 1987 Mar;429(1):67-74. doi: 10.1016/0165-3806(87)90139-8.
In guinea pig brain, alpha 1-noradrenergic receptor concentrations undergo region-specific fluctuations during the first weeks of postnatal life. However, the factors involved in the regulation of these receptors have yet to be identified. In this study, the ontogeny of one possible regulatory factor, norepinephrine, was examined in relation to postnatal changes in alpha 1-receptor levels in several different regions of guinea pig brain. Results from these studies showed that while the activity of the noradrenergic system increased throughout the first weeks of postnatal development in each brain area examined, the concentration of alpha 1-receptors decreased in preoptic area and hypothalamus and increased in cortex. In subsequent experiments, the effects of noradrenergic lesions with 6-hydroxydopamine on alpha 1-receptor levels were assessed to examine the possibility that alpha 1-receptors are differentially sensitive to noradrenergic stimulation in cortex and preoptic area/hypothalamus in immature guinea pigs. Noradrenergic lesions which reduced norepinephrine levels by 87-94% resulted in significant elevations in alpha 1-receptors in all regions examined. These results are discussed with reference to the anatomical distribution of alpha 1-receptors and their regulation by norepinephrine.
在豚鼠脑中，α1 - 去甲肾上腺素能受体浓度在出生后的头几周会经历区域特异性波动。然而，参与这些受体调节的因素尚未确定。在本研究中，研究了一种可能的调节因子去甲肾上腺素的个体发生情况，并将其与豚鼠脑几个不同区域中α1受体水平的产后变化相关联。这些研究结果表明，虽然在所检查的每个脑区中，去甲肾上腺素能系统的活性在出生后发育的头几周内都有所增加，但视前区和下丘脑的α1受体浓度降低，而皮质中的α1受体浓度升高。在随后的实验中，评估了用6 - 羟基多巴胺进行去甲肾上腺素能损伤对α1受体水平的影响，以检验在未成熟豚鼠中，α1受体对皮质和视前区/下丘脑的去甲肾上腺素能刺激具有不同敏感性的可能性。使去甲肾上腺素水平降低87 - 94%的去甲肾上腺素能损伤导致所有检查区域的α1受体显著升高。将结合α1受体的解剖分布及其受去甲肾上腺素调节的情况对这些结果进行讨论。
