College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China; Xuzhou Institute of Agricultural Sciences in Jiangsu Xuhuai District, Xuzhou 221131, China.
College of Food Science and Engineering, Yangzhou University, Yangzhou 225127, China.
Int J Biol Macromol. 2018 Oct 1;117:659-664. doi: 10.1016/j.ijbiomac.2018.05.203. Epub 2018 May 28.
In vivo hepatoprotective effect of a novel arabinogalactan (AG) from black soybean on carbon tetrachloride (CCl)-induced acute liver injury was evaluated for the first time. Our results showed that administration of AG could significantly attenuate the increase in the levels of alkaline phosphatase, alanine transaminase and aspartate transaminase in the serum caused by CCl treatment. AG treatment not only significantly elevated the levels of antioxidant enzymes including superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase; but also increased the levels of non-enzyme antioxidants (glutathione and total antioxidant capacity in liver tissues) when compared with CCl-induced acute liver injury model. In addition, AG significantly reduced lipid peroxidation levels in liver tissues. The hepatoprotective effect of high-dose of AG was comparable to that of silymarin, which served as a positive standard. This study indicated that AG had a protective effect on CCl-induced acute liver injury.
首次评价了来自黑大豆的新型阿拉伯半乳聚糖 (AG) 的体内保肝作用对四氯化碳 (CCl) 诱导的急性肝损伤的影响。我们的结果表明，AG 的给药可显著减轻 CCl 处理引起的血清碱性磷酸酶、丙氨酸转氨酶和天冬氨酸转氨酶水平的升高。AG 处理不仅显著提高了抗氧化酶（包括超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶和谷胱甘肽还原酶）的水平；而且与 CCl 诱导的急性肝损伤模型相比，还增加了肝组织中非酶抗氧化剂（谷胱甘肽和总抗氧化能力）的水平。此外，AG 还显著降低了肝组织中的脂质过氧化水平。高剂量 AG 的保肝作用可与阳性对照药物水飞蓟素相媲美。本研究表明，AG 对 CCl 诱导的急性肝损伤具有保护作用。
