Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Biomed Pharmacother. 2018 Sep;105:130-143. doi: 10.1016/j.biopha.2018.05.097. Epub 2018 May 28.
Ankylosing Spondylitis (AS) is a debilitating rheumatic disease that gives young adults a severe form of arthritis with pain and stiffness in the axial skeleton. After the discovery of Human leukocyte antigen B27 (HLA-B27), several hypotheses have been suggested to uncover the exact etiology of AS. The tendency of HLA-B27 to form unusual structures results in recognition and activation of crucial components in innate immune system. Moreover, cellular and soluble arms of the innate response are frequently observed within the affected tissues. Genome-wide analysis has also shown the association of several innate immune-related pathways and cytokines, which act as the effective therapeutic targets in AS. Given the importance of innate immune system, we present a general overview of innate immune components and their involvement in the pathogenesis of AS. In our belief, this kind of explanation can hopefully provide new perspectives for diagnosis and treatment of these patients in the future.
强直性脊柱炎（AS）是一种使人虚弱的风湿性疾病，会使年轻成年人患上严重的关节炎，导致轴向骨骼疼痛和僵硬。在发现人类白细胞抗原 B27（HLA-B27）之后，人们提出了几种假说，试图揭示 AS 的确切病因。HLA-B27 形成异常结构的倾向导致先天免疫系统中关键成分的识别和激活。此外，在受影响的组织中经常观察到先天免疫的细胞和可溶性臂。全基因组分析还显示了几种先天免疫相关途径和细胞因子的关联，这些途径和细胞因子可作为 AS 的有效治疗靶点。鉴于先天免疫系统的重要性，我们对先天免疫系统成分及其在 AS 发病机制中的作用进行了综述。我们相信，这种解释有望为这些患者的未来诊断和治疗提供新的视角。
