Hazardous Substance and Environmental Management (Interdisciplinary Program), Graduate School, Chulalongkorn University, Bangkok 10330, Thailand.
Environmental Research Institute, Chulalongkorn University, Phayathai Road, Pathumwan, Bangkok 10330, Thailand; Center of Excellence on Hazardous Substance Management (HSM), Phayathai Road, Pathumwan, Bangkok 10330, Thailand.
Chemosphere. 2018 Sep;207:637-648. doi: 10.1016/j.chemosphere.2018.05.125. Epub 2018 May 22.
Food is one of the major sources of arsenic (As) exposure in humans. The objectives of this study were to determine the bioaccessible concentration of As in rice grain sold in Bangkok and to evaluate the potential health risks associated with rice consumption. Polished (n = 32) and husked (n = 17) jasmine rice were collected from local markets. In vitro digestion was performed to determine the bioaccessible As concentrations, which were used for probabilistic health risk assessments in different age groups of the population. Approximately 43.0% and 44.4% of the total As in the grain of polished and husked rice, respectively, was in the form of bioaccessible As. Significantly higher bioaccessible As concentrations were found in husked rice than in polished rice (1.5-3.8 times greater). The concentrations of bioaccessible As in polished and husked rice were lower than the Codex standard for As in rice. The average daily dose of As via rice consumption is equivalent to the daily ingestion of 2 L of water containing approximately 3.2-7.2 μg L of As. Approximately 0.2%-13.7% and 10.7%-55.3% of the population may experience non-carcinogenic effects from polished and husked rice consumption, respectively. Approximately 1%-11.6% of children and 74.1%-99.8% of adults were at risk of cancer. The maximum cancer probabilities were 3 children and 6 adults in 10,000 individuals. The probabilistic risk results indicated that children and adults were at risk of both non-carcinogenic and carcinogenic effects from both types of rice consumption.
食物是人类砷(As)暴露的主要来源之一。本研究的目的是确定在曼谷销售的大米中砷的生物可利用浓度,并评估与大米消费相关的潜在健康风险。从当地市场收集了抛光(n=32)和去壳(n=17)茉莉香米。进行体外消化以确定生物可利用的 As 浓度,用于评估不同年龄段人群的概率健康风险。抛光和去壳大米中约有 43.0%和 44.4%的总 As 以生物可利用的 As 形式存在。与抛光米相比,去壳米中的生物可利用 As 浓度明显更高(高 1.5-3.8 倍)。抛光和去壳米中的生物可利用 As 浓度低于大米中 As 的法典标准。通过食用大米摄入的 As 的平均日剂量相当于每天摄入约 2 L 含有约 3.2-7.2 μg/L 的 As 的水。约 0.2%-13.7%和 10.7%-55.3%的人群可能会因食用抛光和去壳米而产生非致癌影响。约 1%-11.6%的儿童和 74.1%-99.8%的成年人有患癌症的风险。最大癌症概率为每 10000 人中 3 名儿童和 6 名成年人。概率风险结果表明,儿童和成人都有因食用这两种大米而产生非致癌和致癌影响的风险。