Esposito Francesco, Nolasco Agata, Caracciolo Francesco, Velotto Salvatore, Montuori Paolo, Romano Raffaele, Stasi Tommaso, Cirillo Teresa
Department of Public Health, University of Naples Federico II, Via Sergio Pansini, 5, 80131 Naples, Italy.
Department of Agricultural Sciences, University of Naples Federico II, Via Università, 100, 80055 Naples, Italy.
Foods. 2021 Nov 23;10(12):2900. doi: 10.3390/foods10122900.
Acrylamide (also known as 2-propenamide) (AA) is a toxicant that develops in food during high-temperature cooking, and its occurrence is common in biscuits and baked snacks. AA is known for its in vivo neurotoxic and carcinogenic effects, and it is considered a potential carcinogen for humans. Infants may be exposed to AA as early as during weaning through baked food such as biscuits. This study set out to ascertain the concentration of AA in food products intended for infants to assess the dietary exposure to this food contaminant. AA levels were determined through GC/MS and bromination, and dietary exposure was evaluated by a probabilistic method based on Monte Carlo simulation. The results showed that the probability of a carcinogenic exposure is 94%, 92%, and 87%, respectively, for 6-, 12-, and 18-months infants, suggesting the need to delay the introduction of baked products in the diet of weaned infants. It should be noted, however, that these conclusions were drawn considering the biscuits as the primary source of exposure.
丙烯酰胺(又称2-丙烯酰胺)(AA)是一种在高温烹饪过程中于食品中产生的有毒物质,在饼干和烘焙零食中普遍存在。AA因其体内神经毒性和致癌作用而闻名,被认为是对人类的潜在致癌物。婴儿最早可能在断奶期间通过饼干等烘焙食品接触到AA。本研究旨在确定供婴儿食用的食品中AA的浓度,以评估这种食品污染物的膳食暴露情况。通过气相色谱/质谱联用仪(GC/MS)和溴化法测定AA水平,并基于蒙特卡洛模拟的概率方法评估膳食暴露。结果表明,6个月、12个月和18个月大的婴儿致癌暴露概率分别为94%、92%和87%,这表明有必要推迟断奶婴儿饮食中烘焙食品的引入。然而,需要注意的是,这些结论是在将饼干视为主要暴露源的情况下得出的。